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Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial

BACKGROUND: Comparative effectiveness research (CER) documents important differences in antidepressants in terms of efficacy, safety, cost, and burden to the patient. Decision aids can adapt this evidence to help patients participate in making informed choices. In turn, antidepressant therapy will m...

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Autores principales: LeBlanc, Annie, Bodde, Amy E, Branda, Megan E, Yost, Kathleen J, Herrin, Jeph, Williams, Mark D, Shah, Nilay D, Houten, Holly Van, Ruud, Kari L, Pencille, Laurie J, Montori, Victor M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663744/
https://www.ncbi.nlm.nih.gov/pubmed/23782672
http://dx.doi.org/10.1186/1745-6215-14-127
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author LeBlanc, Annie
Bodde, Amy E
Branda, Megan E
Yost, Kathleen J
Herrin, Jeph
Williams, Mark D
Shah, Nilay D
Houten, Holly Van
Ruud, Kari L
Pencille, Laurie J
Montori, Victor M
author_facet LeBlanc, Annie
Bodde, Amy E
Branda, Megan E
Yost, Kathleen J
Herrin, Jeph
Williams, Mark D
Shah, Nilay D
Houten, Holly Van
Ruud, Kari L
Pencille, Laurie J
Montori, Victor M
author_sort LeBlanc, Annie
collection PubMed
description BACKGROUND: Comparative effectiveness research (CER) documents important differences in antidepressants in terms of efficacy, safety, cost, and burden to the patient. Decision aids can adapt this evidence to help patients participate in making informed choices. In turn, antidepressant therapy will more likely reflect patients’ values and context, leading to improved adherence and mood outcomes. METHODS/DESIGN: The objective of this study is to develop the Depression Medication Choice decision aid for use during primary care encounters, and to test its efficacy by conducting a clustered practical randomized trial comparing the decision aid to usual depression care in primary care practices. We will use a novel practice-based, patient-centered approach based on participatory action research that involves a multidisciplinary team of designers, investigators, clinicians, patient representatives, and other stakeholders for the development of the decision aid. We will then conduct a clustered practical randomized trial enrolling clinicians and their patients (n = 300) with moderate to severe depression from rural, suburban and inner city primary care practices (n = 10). The intervention will consist of the use of the depression medication choice decision aid during the clinical encounter. This trial will generate preliminary evidence of the relative impact of the decision aid on patient involvement in decision making, decision making quality, patient knowledge, and 6-month measures of medication adherence and mental health compared to usual depression care. DISCUSSION: Upon completion of the proposed research, we will have developed and evaluated the efficacy of the decision aid depression medication choice as a novel translational tool for CER in depression treatment, engaged patients with depression in their care, and refined the process by which we conduct practice-based trials with limited research footprint. TRIAL REGISTRATION: Clinical Trials.gov: NCT01502891
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spelling pubmed-36637442013-05-25 Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial LeBlanc, Annie Bodde, Amy E Branda, Megan E Yost, Kathleen J Herrin, Jeph Williams, Mark D Shah, Nilay D Houten, Holly Van Ruud, Kari L Pencille, Laurie J Montori, Victor M Trials Study Protocol BACKGROUND: Comparative effectiveness research (CER) documents important differences in antidepressants in terms of efficacy, safety, cost, and burden to the patient. Decision aids can adapt this evidence to help patients participate in making informed choices. In turn, antidepressant therapy will more likely reflect patients’ values and context, leading to improved adherence and mood outcomes. METHODS/DESIGN: The objective of this study is to develop the Depression Medication Choice decision aid for use during primary care encounters, and to test its efficacy by conducting a clustered practical randomized trial comparing the decision aid to usual depression care in primary care practices. We will use a novel practice-based, patient-centered approach based on participatory action research that involves a multidisciplinary team of designers, investigators, clinicians, patient representatives, and other stakeholders for the development of the decision aid. We will then conduct a clustered practical randomized trial enrolling clinicians and their patients (n = 300) with moderate to severe depression from rural, suburban and inner city primary care practices (n = 10). The intervention will consist of the use of the depression medication choice decision aid during the clinical encounter. This trial will generate preliminary evidence of the relative impact of the decision aid on patient involvement in decision making, decision making quality, patient knowledge, and 6-month measures of medication adherence and mental health compared to usual depression care. DISCUSSION: Upon completion of the proposed research, we will have developed and evaluated the efficacy of the decision aid depression medication choice as a novel translational tool for CER in depression treatment, engaged patients with depression in their care, and refined the process by which we conduct practice-based trials with limited research footprint. TRIAL REGISTRATION: Clinical Trials.gov: NCT01502891 BioMed Central 2013-05-07 /pmc/articles/PMC3663744/ /pubmed/23782672 http://dx.doi.org/10.1186/1745-6215-14-127 Text en Copyright © 2013 LeBlanc et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol
LeBlanc, Annie
Bodde, Amy E
Branda, Megan E
Yost, Kathleen J
Herrin, Jeph
Williams, Mark D
Shah, Nilay D
Houten, Holly Van
Ruud, Kari L
Pencille, Laurie J
Montori, Victor M
Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial
title Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial
title_full Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial
title_fullStr Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial
title_full_unstemmed Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial
title_short Translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial
title_sort translating comparative effectiveness of depression medications into practice by comparing the depression medication choice decision aid to usual care: study protocol for a randomized controlled trial
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663744/
https://www.ncbi.nlm.nih.gov/pubmed/23782672
http://dx.doi.org/10.1186/1745-6215-14-127
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