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Pemetrexed Induced Thymidylate Synthase Inhibition in Non-Small Cell Lung Cancer Patients: A Pilot Study with 3′-Deoxy-3′-[(18)F]fluorothymidine Positron Emission Tomography

OBJECTIVES: Pemetrexed is a thymidylate synthase (TS) inhibitor and is effective in non-small cell lung cancer (NSCLC). 3′-deoxy-3′-[18F]fluorothymidine ((18)F-FLT), a proliferation marker, could potentially identify tumor specific TS-inhibition. The aim of this study was to investigate the effect o...

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Detalles Bibliográficos
Autores principales:	Frings, Virginie, van der Veldt, Astrid A. M., Boellaard, Ronald, Herder, Gerarda J. M., Giovannetti, Elisa, Honeywell, Richard, Peters, Godefridus J., Thunnissen, Erik, Hoekstra, Otto S., Smit, Egbert F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663749/ https://www.ncbi.nlm.nih.gov/pubmed/23717468 http://dx.doi.org/10.1371/journal.pone.0063705

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