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HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life
Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to in...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663876/ https://www.ncbi.nlm.nih.gov/pubmed/23299618 http://dx.doi.org/10.1038/mi.2012.107 |
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author | Yates, N L Stacey, A R Nolen, T L Vandergrift, N A Moody, M A Montefiori, D C Weinhold, K J Blattner, W A Borrow, P Shattock, R Cohen, M S Haynes, B F Tomaras, G D |
author_facet | Yates, N L Stacey, A R Nolen, T L Vandergrift, N A Moody, M A Montefiori, D C Weinhold, K J Blattner, W A Borrow, P Shattock, R Cohen, M S Haynes, B F Tomaras, G D |
author_sort | Yates, N L |
collection | PubMed |
description | Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to induce protective Ab responses by vaccination. Genital fluids from patients within the earliest stages of acute HIV-1 infection (Fiebig I–VI) were examined for multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig)A Abs were frequently elicited in both plasma and mucosal fluids within the first weeks of transmission. However, shortly after induction, these initial mucosal gp41 Env IgA Abs rapidly declined with a t(1/2) of ∼2.7 days. B-cell-activating factor belonging to the TNF family (BAFF) was elevated immediately preceding the appearance of gp41 Abs, likely contributing to an initial T-independent Ab response. HIV-1 transmission frequently elicits mucosal HIV-1 envelope-specific IgA responses targeted to gp41 that have a short half-life. |
format | Online Article Text |
id | pubmed-3663876 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-36638762013-06-18 HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life Yates, N L Stacey, A R Nolen, T L Vandergrift, N A Moody, M A Montefiori, D C Weinhold, K J Blattner, W A Borrow, P Shattock, R Cohen, M S Haynes, B F Tomaras, G D Mucosal Immunol Article Prevention of HIV-1 transmission at mucosal surfaces will likely require durable pre-existing mucosal anti-HIV-1 antibodies (Abs). Defining the ontogeny, specificities and potentially protective nature of the initial mucosal virus-specific B-cell response will be critical for understanding how to induce protective Ab responses by vaccination. Genital fluids from patients within the earliest stages of acute HIV-1 infection (Fiebig I–VI) were examined for multiple anti-HIV specificities. Gp41 (but not gp120) Env immunoglobulin (Ig)A Abs were frequently elicited in both plasma and mucosal fluids within the first weeks of transmission. However, shortly after induction, these initial mucosal gp41 Env IgA Abs rapidly declined with a t(1/2) of ∼2.7 days. B-cell-activating factor belonging to the TNF family (BAFF) was elevated immediately preceding the appearance of gp41 Abs, likely contributing to an initial T-independent Ab response. HIV-1 transmission frequently elicits mucosal HIV-1 envelope-specific IgA responses targeted to gp41 that have a short half-life. Nature Publishing Group 2013-07 2013-01-09 /pmc/articles/PMC3663876/ /pubmed/23299618 http://dx.doi.org/10.1038/mi.2012.107 Text en Copyright © 2013 Society for Mucosal Immunology http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under the Creative Commons Attribution-NonCommercial-No Derivative Works 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/ |
spellingShingle | Article Yates, N L Stacey, A R Nolen, T L Vandergrift, N A Moody, M A Montefiori, D C Weinhold, K J Blattner, W A Borrow, P Shattock, R Cohen, M S Haynes, B F Tomaras, G D HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life |
title | HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life |
title_full | HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life |
title_fullStr | HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life |
title_full_unstemmed | HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life |
title_short | HIV-1 gp41 envelope IgA is frequently elicited after transmission but has an initial short response half-life |
title_sort | hiv-1 gp41 envelope iga is frequently elicited after transmission but has an initial short response half-life |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663876/ https://www.ncbi.nlm.nih.gov/pubmed/23299618 http://dx.doi.org/10.1038/mi.2012.107 |
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