A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus

Metastatic insulinomas may sometimes present with recurrent life-threatening hypoglycemia episodes. Such patients usually fail to respond to various therapeutic agents which causes constant dextrose infusion requirement. Herein, we present a resistant case of inoperable malignant insulinoma who was...

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Autores principales: Bozkirli, Emre, Bakiner, Okan, Abali, Huseyin, Andic, Cagatay, Yapar, Ali Fuat, Kayaselcuk, Fazilet, Ertorer, Eda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664472/
https://www.ncbi.nlm.nih.gov/pubmed/23738155
http://dx.doi.org/10.1155/2013/636175
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author Bozkirli, Emre
Bakiner, Okan
Abali, Huseyin
Andic, Cagatay
Yapar, Ali Fuat
Kayaselcuk, Fazilet
Ertorer, Eda
author_facet Bozkirli, Emre
Bakiner, Okan
Abali, Huseyin
Andic, Cagatay
Yapar, Ali Fuat
Kayaselcuk, Fazilet
Ertorer, Eda
author_sort Bozkirli, Emre
collection PubMed
description Metastatic insulinomas may sometimes present with recurrent life-threatening hypoglycemia episodes. Such patients usually fail to respond to various therapeutic agents which causes constant dextrose infusion requirement. Herein, we present a resistant case of inoperable malignant insulinoma who was treated with many therapeutic agents and interventions including somatostatin analogues, Yttrium-90 radioembolization, everolimus, radiotherapy, and chemoembolization. Close blood sugar monitorization during these therapies showed the most favourable response with everolimus. Everolimus treatment resulted in rapid improvement of hypoglycemia episodes, letting us discontinue dextrose infusion and discharge the patient. However, experience with everolimus in such patients is still limited, and more precise data can be obtained with the increasing use of this agent for neuroendocrine tumours.
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spelling pubmed-36644722013-06-04 A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus Bozkirli, Emre Bakiner, Okan Abali, Huseyin Andic, Cagatay Yapar, Ali Fuat Kayaselcuk, Fazilet Ertorer, Eda Case Rep Endocrinol Case Report Metastatic insulinomas may sometimes present with recurrent life-threatening hypoglycemia episodes. Such patients usually fail to respond to various therapeutic agents which causes constant dextrose infusion requirement. Herein, we present a resistant case of inoperable malignant insulinoma who was treated with many therapeutic agents and interventions including somatostatin analogues, Yttrium-90 radioembolization, everolimus, radiotherapy, and chemoembolization. Close blood sugar monitorization during these therapies showed the most favourable response with everolimus. Everolimus treatment resulted in rapid improvement of hypoglycemia episodes, letting us discontinue dextrose infusion and discharge the patient. However, experience with everolimus in such patients is still limited, and more precise data can be obtained with the increasing use of this agent for neuroendocrine tumours. Hindawi Publishing Corporation 2013 2013-05-08 /pmc/articles/PMC3664472/ /pubmed/23738155 http://dx.doi.org/10.1155/2013/636175 Text en Copyright © 2013 Emre Bozkirli et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Bozkirli, Emre
Bakiner, Okan
Abali, Huseyin
Andic, Cagatay
Yapar, Ali Fuat
Kayaselcuk, Fazilet
Ertorer, Eda
A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus
title A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus
title_full A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus
title_fullStr A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus
title_full_unstemmed A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus
title_short A Case of Inoperable Malignant Insulinoma with Resistant Hypoglycemia Who Experienced the Most Significant Clinical Improvement with Everolimus
title_sort case of inoperable malignant insulinoma with resistant hypoglycemia who experienced the most significant clinical improvement with everolimus
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664472/
https://www.ncbi.nlm.nih.gov/pubmed/23738155
http://dx.doi.org/10.1155/2013/636175
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