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Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides

The resolution of inflammation is now known to be an active process, armed with a multitude of mediators both lipid and protein in nature. Melanocortins are peptides endowed with considerable promise with their proresolution and anti-inflammatory effects in preclinical models of inflammatory disease...

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Detalles Bibliográficos
Autores principales: Ahmed, Tazeen J., Montero-Melendez, Trinidad, Perretti, Mauro, Pitzalis, Costantino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664505/
https://www.ncbi.nlm.nih.gov/pubmed/23738228
http://dx.doi.org/10.1155/2013/985815
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author Ahmed, Tazeen J.
Montero-Melendez, Trinidad
Perretti, Mauro
Pitzalis, Costantino
author_facet Ahmed, Tazeen J.
Montero-Melendez, Trinidad
Perretti, Mauro
Pitzalis, Costantino
author_sort Ahmed, Tazeen J.
collection PubMed
description The resolution of inflammation is now known to be an active process, armed with a multitude of mediators both lipid and protein in nature. Melanocortins are peptides endowed with considerable promise with their proresolution and anti-inflammatory effects in preclinical models of inflammatory disease, with tissue protective effects. These peptides and their targets are appealing because they can be seen as a natural way of inducing these effects as they harness endogenous pathways of control. Whereas most of the information generated about these mediators derives from several acute models of inflammation (such as zymosan induced peritonitis), there is some indication that these mediators may inhibit chronic inflammation by modulating cytokines, chemokines, and leukocyte apoptosis. In addition, proresolving mediators and their mimics have often been tested alongside therapeutic protocols, hence have been tested in settings more relevant to real life clinical scenarios. We provide here an overview on some of these mediators with a focus on melanocortin peptides and receptors, proposing that they may unveil new opportunities for innovative treatments of inflammatory arthritis.
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spelling pubmed-36645052013-06-04 Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides Ahmed, Tazeen J. Montero-Melendez, Trinidad Perretti, Mauro Pitzalis, Costantino Int J Inflam Review Article The resolution of inflammation is now known to be an active process, armed with a multitude of mediators both lipid and protein in nature. Melanocortins are peptides endowed with considerable promise with their proresolution and anti-inflammatory effects in preclinical models of inflammatory disease, with tissue protective effects. These peptides and their targets are appealing because they can be seen as a natural way of inducing these effects as they harness endogenous pathways of control. Whereas most of the information generated about these mediators derives from several acute models of inflammation (such as zymosan induced peritonitis), there is some indication that these mediators may inhibit chronic inflammation by modulating cytokines, chemokines, and leukocyte apoptosis. In addition, proresolving mediators and their mimics have often been tested alongside therapeutic protocols, hence have been tested in settings more relevant to real life clinical scenarios. We provide here an overview on some of these mediators with a focus on melanocortin peptides and receptors, proposing that they may unveil new opportunities for innovative treatments of inflammatory arthritis. Hindawi Publishing Corporation 2013 2013-05-07 /pmc/articles/PMC3664505/ /pubmed/23738228 http://dx.doi.org/10.1155/2013/985815 Text en Copyright © 2013 Tazeen J. Ahmed et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ahmed, Tazeen J.
Montero-Melendez, Trinidad
Perretti, Mauro
Pitzalis, Costantino
Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides
title Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides
title_full Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides
title_fullStr Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides
title_full_unstemmed Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides
title_short Curbing Inflammation through Endogenous Pathways: Focus on Melanocortin Peptides
title_sort curbing inflammation through endogenous pathways: focus on melanocortin peptides
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664505/
https://www.ncbi.nlm.nih.gov/pubmed/23738228
http://dx.doi.org/10.1155/2013/985815
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