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Role of the olivo-cerebellar complex in motor learning and control
How is the cerebellum capable of efficient motor learning and control despite very low firing of the inferior olive (IO) inputs, which are postulated to carry errors needed for learning and contribute to on-line motor control? IO neurons form the largest electrically coupled network in the adult hum...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664774/ https://www.ncbi.nlm.nih.gov/pubmed/23754983 http://dx.doi.org/10.3389/fncir.2013.00094 |
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author | Schweighofer, Nicolas Lang, Eric J. Kawato, Mitsuo |
author_facet | Schweighofer, Nicolas Lang, Eric J. Kawato, Mitsuo |
author_sort | Schweighofer, Nicolas |
collection | PubMed |
description | How is the cerebellum capable of efficient motor learning and control despite very low firing of the inferior olive (IO) inputs, which are postulated to carry errors needed for learning and contribute to on-line motor control? IO neurons form the largest electrically coupled network in the adult human brain. Here, we discuss how intermediate coupling strengths can lead to chaotic resonance and increase information transmission of the error signal despite the very low IO firing rate. This increased information transmission can then lead to more efficient learning than with weak or strong coupling. In addition, we argue that a dynamic modulation of IO electrical coupling via the Purkinje cell-deep cerebellar neurons – IO triangle could speed up learning and improve on-line control. Initially strong coupling would allow transmission of large errors to multiple functionally related Purkinje cells, resulting in fast but coarse learning as well as significant effects on deep cerebellar nucleus and on-line motor control. In the late phase of learning decreased coupling would allow desynchronized IO firing, allowing high-fidelity transmission of error, resulting in slower but fine learning, and little on-line motor control effects. |
format | Online Article Text |
id | pubmed-3664774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36647742013-06-10 Role of the olivo-cerebellar complex in motor learning and control Schweighofer, Nicolas Lang, Eric J. Kawato, Mitsuo Front Neural Circuits Neuroscience How is the cerebellum capable of efficient motor learning and control despite very low firing of the inferior olive (IO) inputs, which are postulated to carry errors needed for learning and contribute to on-line motor control? IO neurons form the largest electrically coupled network in the adult human brain. Here, we discuss how intermediate coupling strengths can lead to chaotic resonance and increase information transmission of the error signal despite the very low IO firing rate. This increased information transmission can then lead to more efficient learning than with weak or strong coupling. In addition, we argue that a dynamic modulation of IO electrical coupling via the Purkinje cell-deep cerebellar neurons – IO triangle could speed up learning and improve on-line control. Initially strong coupling would allow transmission of large errors to multiple functionally related Purkinje cells, resulting in fast but coarse learning as well as significant effects on deep cerebellar nucleus and on-line motor control. In the late phase of learning decreased coupling would allow desynchronized IO firing, allowing high-fidelity transmission of error, resulting in slower but fine learning, and little on-line motor control effects. Frontiers Media S.A. 2013-05-28 /pmc/articles/PMC3664774/ /pubmed/23754983 http://dx.doi.org/10.3389/fncir.2013.00094 Text en Copyright © Schweighofer, Lang and Kawato. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Neuroscience Schweighofer, Nicolas Lang, Eric J. Kawato, Mitsuo Role of the olivo-cerebellar complex in motor learning and control |
title | Role of the olivo-cerebellar complex in motor learning and control |
title_full | Role of the olivo-cerebellar complex in motor learning and control |
title_fullStr | Role of the olivo-cerebellar complex in motor learning and control |
title_full_unstemmed | Role of the olivo-cerebellar complex in motor learning and control |
title_short | Role of the olivo-cerebellar complex in motor learning and control |
title_sort | role of the olivo-cerebellar complex in motor learning and control |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664774/ https://www.ncbi.nlm.nih.gov/pubmed/23754983 http://dx.doi.org/10.3389/fncir.2013.00094 |
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