Proofreading exonuclease on a tether: the complex between the E. coli DNA polymerase III subunits α, ε, θ and β reveals a highly flexible arrangement of the proofreading domain

A complex of the three (αεθ) core subunits and the β(2) sliding clamp is responsible for DNA synthesis by Pol III, the Escherichia coli chromosomal DNA replicase. The 1.7 Å crystal structure of a complex between the PHP domain of α (polymerase) and the C-terminal segment of ε (proofreading exonuclea...

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Detalles Bibliográficos
Autores principales: Ozawa, Kiyoshi, Horan, Nicholas P., Robinson, Andrew, Yagi, Hiromasa, Hill, Flynn R., Jergic, Slobodan, Xu, Zhi-Qiang, Loscha, Karin V., Li, Nan, Tehei, Moeava, Oakley, Aaron J., Otting, Gottfried, Huber, Thomas, Dixon, Nicholas E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664792/
https://www.ncbi.nlm.nih.gov/pubmed/23580545
http://dx.doi.org/10.1093/nar/gkt162

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