Ribosomal protein S7 regulates arsenite-induced GADD45α expression by attenuating MDM2-mediated GADD45α ubiquitination and degradation

The stress-responding protein, GADD45α, plays important roles in cell cycle checkpoint, DNA repair and apoptosis. In our recent study, we demonstrate that GADD45α undergoes a dynamic ubiquitination and degradation in vivo, which process can be blocked by the cytotoxic reagent, arsenite, resulting in...

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Detalles Bibliográficos
Autores principales: Gao, Ming, Li, Xiaoguang, Dong, Wen, Jin, Rui, Ma, Hanghang, Yang, Pingxun, Hu, Meiru, Li, Yi, Hao, Yi, Yuan, Shengtao, Huang, Junjian, Song, Lun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664810/
https://www.ncbi.nlm.nih.gov/pubmed/23563151
http://dx.doi.org/10.1093/nar/gkt223

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