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Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance

One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ t...

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Autores principales: Ruiz, Paulina, Maldonado, Paula, Hidalgo, Yessia, Gleisner, Alejandra, Sauma, Daniela, Silva, Cinthia, Saez, Juan Jose, Nuñez, Sarah, Rosemblatt, Mario, Bono, Maria Rosa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665173/
https://www.ncbi.nlm.nih.gov/pubmed/23762087
http://dx.doi.org/10.1155/2013/210506
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author Ruiz, Paulina
Maldonado, Paula
Hidalgo, Yessia
Gleisner, Alejandra
Sauma, Daniela
Silva, Cinthia
Saez, Juan Jose
Nuñez, Sarah
Rosemblatt, Mario
Bono, Maria Rosa
author_facet Ruiz, Paulina
Maldonado, Paula
Hidalgo, Yessia
Gleisner, Alejandra
Sauma, Daniela
Silva, Cinthia
Saez, Juan Jose
Nuñez, Sarah
Rosemblatt, Mario
Bono, Maria Rosa
author_sort Ruiz, Paulina
collection PubMed
description One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ transplantation between genetically dissimilar individuals (allogeneic grafting) is a procedure widely used as a therapeutic alternative in cases of organ failure, hematological disease treatment, and some malignancies. Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. Here, we describe the different treatments and some of the novel immunotherapeutic strategies undertaken to induce transplantation tolerance.
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spelling pubmed-36651732013-06-12 Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance Ruiz, Paulina Maldonado, Paula Hidalgo, Yessia Gleisner, Alejandra Sauma, Daniela Silva, Cinthia Saez, Juan Jose Nuñez, Sarah Rosemblatt, Mario Bono, Maria Rosa Clin Dev Immunol Review Article One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ transplantation between genetically dissimilar individuals (allogeneic grafting) is a procedure widely used as a therapeutic alternative in cases of organ failure, hematological disease treatment, and some malignancies. Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. Here, we describe the different treatments and some of the novel immunotherapeutic strategies undertaken to induce transplantation tolerance. Hindawi Publishing Corporation 2013 2013-05-12 /pmc/articles/PMC3665173/ /pubmed/23762087 http://dx.doi.org/10.1155/2013/210506 Text en Copyright © 2013 Paulina Ruiz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Ruiz, Paulina
Maldonado, Paula
Hidalgo, Yessia
Gleisner, Alejandra
Sauma, Daniela
Silva, Cinthia
Saez, Juan Jose
Nuñez, Sarah
Rosemblatt, Mario
Bono, Maria Rosa
Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
title Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
title_full Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
title_fullStr Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
title_full_unstemmed Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
title_short Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
title_sort transplant tolerance: new insights and strategies for long-term allograft acceptance
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665173/
https://www.ncbi.nlm.nih.gov/pubmed/23762087
http://dx.doi.org/10.1155/2013/210506
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