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Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance
One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ t...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665173/ https://www.ncbi.nlm.nih.gov/pubmed/23762087 http://dx.doi.org/10.1155/2013/210506 |
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author | Ruiz, Paulina Maldonado, Paula Hidalgo, Yessia Gleisner, Alejandra Sauma, Daniela Silva, Cinthia Saez, Juan Jose Nuñez, Sarah Rosemblatt, Mario Bono, Maria Rosa |
author_facet | Ruiz, Paulina Maldonado, Paula Hidalgo, Yessia Gleisner, Alejandra Sauma, Daniela Silva, Cinthia Saez, Juan Jose Nuñez, Sarah Rosemblatt, Mario Bono, Maria Rosa |
author_sort | Ruiz, Paulina |
collection | PubMed |
description | One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ transplantation between genetically dissimilar individuals (allogeneic grafting) is a procedure widely used as a therapeutic alternative in cases of organ failure, hematological disease treatment, and some malignancies. Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. Here, we describe the different treatments and some of the novel immunotherapeutic strategies undertaken to induce transplantation tolerance. |
format | Online Article Text |
id | pubmed-3665173 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36651732013-06-12 Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance Ruiz, Paulina Maldonado, Paula Hidalgo, Yessia Gleisner, Alejandra Sauma, Daniela Silva, Cinthia Saez, Juan Jose Nuñez, Sarah Rosemblatt, Mario Bono, Maria Rosa Clin Dev Immunol Review Article One of the greatest advances in medicine during the past century is the introduction of organ transplantation. This therapeutic strategy designed to treat organ failure and organ dysfunction allows to prolong the survival of many patients that are faced with no other treatment option. Today, organ transplantation between genetically dissimilar individuals (allogeneic grafting) is a procedure widely used as a therapeutic alternative in cases of organ failure, hematological disease treatment, and some malignancies. Despite the potential of organ transplantation, the administration of immunosuppressive drugs required for allograft acceptance induces severe immunosuppression in transplanted patients, which leads to serious side effects such as infection with opportunistic pathogens and the occurrence of neoplasias, in addition to the known intrinsic toxicity of these drugs. To solve this setback in allotransplantation, researchers have focused on manipulating the immune response in order to create a state of tolerance rather than unspecific immunosuppression. Here, we describe the different treatments and some of the novel immunotherapeutic strategies undertaken to induce transplantation tolerance. Hindawi Publishing Corporation 2013 2013-05-12 /pmc/articles/PMC3665173/ /pubmed/23762087 http://dx.doi.org/10.1155/2013/210506 Text en Copyright © 2013 Paulina Ruiz et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Ruiz, Paulina Maldonado, Paula Hidalgo, Yessia Gleisner, Alejandra Sauma, Daniela Silva, Cinthia Saez, Juan Jose Nuñez, Sarah Rosemblatt, Mario Bono, Maria Rosa Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
title | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
title_full | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
title_fullStr | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
title_full_unstemmed | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
title_short | Transplant Tolerance: New Insights and Strategies for Long-Term Allograft Acceptance |
title_sort | transplant tolerance: new insights and strategies for long-term allograft acceptance |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665173/ https://www.ncbi.nlm.nih.gov/pubmed/23762087 http://dx.doi.org/10.1155/2013/210506 |
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