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Update on the Diagnosis and Management of Refractory Coeliac Disease

A small subset of coeliac disease (CD) patients experiences persisting or recurring symptoms despite strict adherence to a gluten-free diet (GFD). When other causes of villous atrophy have been excluded, these patients are referred to as refractory celiac disease (RCD) patients. RCD can be divided i...

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Detalles Bibliográficos
Autores principales: Nijeboer, Petula, van Wanrooij, Roy L. J., Tack, Greetje J., Mulder, Chris J. J., Bouma, Gerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665175/
https://www.ncbi.nlm.nih.gov/pubmed/23762036
http://dx.doi.org/10.1155/2013/518483
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author Nijeboer, Petula
van Wanrooij, Roy L. J.
Tack, Greetje J.
Mulder, Chris J. J.
Bouma, Gerd
author_facet Nijeboer, Petula
van Wanrooij, Roy L. J.
Tack, Greetje J.
Mulder, Chris J. J.
Bouma, Gerd
author_sort Nijeboer, Petula
collection PubMed
description A small subset of coeliac disease (CD) patients experiences persisting or recurring symptoms despite strict adherence to a gluten-free diet (GFD). When other causes of villous atrophy have been excluded, these patients are referred to as refractory celiac disease (RCD) patients. RCD can be divided in two types based on the absence (type I) or presence (type II) of an, usually clonal, intraepithelial lymphocyte population with aberrant phenotype. RCDI usually runs a benign course and may be difficult to be differentiated from uncomplicated, slow responding CD. In contrast, RCDII can be defined as low-grade intraepithelial lymphoma and frequently transforms into an aggressive enteropathy associated T-cell lymphoma with dismal prognosis. This paper describes the clinical characteristics of RCDI and RCDII, diagnostic approach, and the latest insights in treatment options.
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spelling pubmed-36651752013-06-12 Update on the Diagnosis and Management of Refractory Coeliac Disease Nijeboer, Petula van Wanrooij, Roy L. J. Tack, Greetje J. Mulder, Chris J. J. Bouma, Gerd Gastroenterol Res Pract Review Article A small subset of coeliac disease (CD) patients experiences persisting or recurring symptoms despite strict adherence to a gluten-free diet (GFD). When other causes of villous atrophy have been excluded, these patients are referred to as refractory celiac disease (RCD) patients. RCD can be divided in two types based on the absence (type I) or presence (type II) of an, usually clonal, intraepithelial lymphocyte population with aberrant phenotype. RCDI usually runs a benign course and may be difficult to be differentiated from uncomplicated, slow responding CD. In contrast, RCDII can be defined as low-grade intraepithelial lymphoma and frequently transforms into an aggressive enteropathy associated T-cell lymphoma with dismal prognosis. This paper describes the clinical characteristics of RCDI and RCDII, diagnostic approach, and the latest insights in treatment options. Hindawi Publishing Corporation 2013 2013-05-09 /pmc/articles/PMC3665175/ /pubmed/23762036 http://dx.doi.org/10.1155/2013/518483 Text en Copyright © 2013 Petula Nijeboer et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nijeboer, Petula
van Wanrooij, Roy L. J.
Tack, Greetje J.
Mulder, Chris J. J.
Bouma, Gerd
Update on the Diagnosis and Management of Refractory Coeliac Disease
title Update on the Diagnosis and Management of Refractory Coeliac Disease
title_full Update on the Diagnosis and Management of Refractory Coeliac Disease
title_fullStr Update on the Diagnosis and Management of Refractory Coeliac Disease
title_full_unstemmed Update on the Diagnosis and Management of Refractory Coeliac Disease
title_short Update on the Diagnosis and Management of Refractory Coeliac Disease
title_sort update on the diagnosis and management of refractory coeliac disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665175/
https://www.ncbi.nlm.nih.gov/pubmed/23762036
http://dx.doi.org/10.1155/2013/518483
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