Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature

Microangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Etiologies can include medications, infections, cancers, or transplantation. We present a pat...

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Detalles Bibliográficos
Autores principales: Shah, Gunjan, Yamin, Hanah, Smith, Hedy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665239/
https://www.ncbi.nlm.nih.gov/pubmed/23762670
http://dx.doi.org/10.1155/2013/130978
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author Shah, Gunjan
Yamin, Hanah
Smith, Hedy
author_facet Shah, Gunjan
Yamin, Hanah
Smith, Hedy
author_sort Shah, Gunjan
collection PubMed
description Microangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Etiologies can include medications, infections, cancers, or transplantation. We present a patient with a history of rectal cancer treated with mitomycin-C who developed MAHA, acute kidney injury, and thrombocytopenia 6 months after completing therapy and to did not respond the plasmapheresis or steroids. She was treated with four weekly doses of rituximab with full recovery.
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spelling pubmed-36652392013-06-12 Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature Shah, Gunjan Yamin, Hanah Smith, Hedy Case Rep Hematol Case Report Microangiopathic hemolytic anemia (MAHA), thrombocytopenia, fever, renal failure, and neurologic symptoms comprise the cardinal features of thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Etiologies can include medications, infections, cancers, or transplantation. We present a patient with a history of rectal cancer treated with mitomycin-C who developed MAHA, acute kidney injury, and thrombocytopenia 6 months after completing therapy and to did not respond the plasmapheresis or steroids. She was treated with four weekly doses of rituximab with full recovery. Hindawi Publishing Corporation 2013 2013-05-12 /pmc/articles/PMC3665239/ /pubmed/23762670 http://dx.doi.org/10.1155/2013/130978 Text en Copyright © 2013 Gunjan Shah et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Shah, Gunjan
Yamin, Hanah
Smith, Hedy
Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_full Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_fullStr Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_full_unstemmed Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_short Mitomycin-C-Induced TTP/HUS Treated Successfully with Rituximab: Case Report and Review of the Literature
title_sort mitomycin-c-induced ttp/hus treated successfully with rituximab: case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665239/
https://www.ncbi.nlm.nih.gov/pubmed/23762670
http://dx.doi.org/10.1155/2013/130978
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AT yaminhanah mitomycincinducedttphustreatedsuccessfullywithrituximabcasereportandreviewoftheliterature
AT smithhedy mitomycincinducedttphustreatedsuccessfullywithrituximabcasereportandreviewoftheliterature

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