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Scaffold-Focused Virtual Screening: Prospective Application to the Discovery of TTK Inhibitors
[Image: see text] We describe and apply a scaffold-focused virtual screen based upon scaffold trees to the mitotic kinase TTK (MPS1). Using level 1 of the scaffold tree, we perform both 2D and 3D similarity searches between a query scaffold and a level 1 scaffold library derived from a 2 million com...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2013
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665241/ https://www.ncbi.nlm.nih.gov/pubmed/23672464 http://dx.doi.org/10.1021/ci400100c |