Systematic review and stratified meta-analysis of the efficacy of RhoA and Rho kinase inhibitors in animal models of ischaemic stroke

BACKGROUND: There is currently only one clinically approved drug, tissue plasminogen activator (tPA), for the treatment of acute ischaemic stroke. The RhoA pathway, including RhoA and its downstream effector Rho kinase (ROCK), has been identified as a possible therapeutic target. Our aim was to asse...

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Detalles Bibliográficos
Autores principales: Vesterinen, Hanna M, Currie, Gillian L, Carter, Samantha, Mee, Sarah, Watzlawick, Ralf, Egan, Kieren J, Macleod, Malcolm R, Sena, Emily S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665471/
https://www.ncbi.nlm.nih.gov/pubmed/23687965
http://dx.doi.org/10.1186/2046-4053-2-33

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