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The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer
BACKGROUND: TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between potentially functional SNPs in the miRNA bin...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665554/ https://www.ncbi.nlm.nih.gov/pubmed/23724109 http://dx.doi.org/10.1371/journal.pone.0064973 |
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author | Xu, Yu Ma, Hongxia Yu, Hongping Liu, Zhensheng Wang, Li-E Tan, Dongfeng Muddasani, Ramya Lu, Victoria Ajani, Jaffer A. Wang, Yanong Wei, Qingyi |
author_facet | Xu, Yu Ma, Hongxia Yu, Hongping Liu, Zhensheng Wang, Li-E Tan, Dongfeng Muddasani, Ramya Lu, Victoria Ajani, Jaffer A. Wang, Yanong Wei, Qingyi |
author_sort | Xu, Yu |
collection | PubMed |
description | BACKGROUND: TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between potentially functional SNPs in the miRNA binding sites of the 3′UTR of TNFAIP2 and gastric cancer risk in a US population. METHODS: We conducted a case-control study of 301 gastric cancer patients and 313 cancer-free controls frequency-matched by age, sex and ethnicity. We genotyped four selected TNFAIP2 SNPs (rs8126 T>C, rs710100 G>A, rs1052912 G>A and rs1052823 G>T) and used the logistic regression analysis to assess associations of these SNPs with cancer risk. RESULTS: The rs8126 CC genotype was associated with a significantly elevated risk of gastric cancer (adjusted OR = 2.00, 95% CI = 1.09–3.64 and P = 0.024), compared with the combined rs8126 TT+TC genotypes, particularly in current drinkers. However, none of other TNFAIP2 SNPs was associated with risk of gastric cancer. CONCLUSIONS: Our data suggested that the TNFAIP2 miRNA binding site rs8126 T>C SNP may be a marker for susceptibility to gastric cancer, and this finding requires further validation by larger studies. |
format | Online Article Text |
id | pubmed-3665554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36655542013-05-30 The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer Xu, Yu Ma, Hongxia Yu, Hongping Liu, Zhensheng Wang, Li-E Tan, Dongfeng Muddasani, Ramya Lu, Victoria Ajani, Jaffer A. Wang, Yanong Wei, Qingyi PLoS One Research Article BACKGROUND: TNFAIP2 is a crucial gene involved in apoptosis. Single nucleotide polymorphisms (SNPs) in its miRNA binding sites could modulate functions of the miRNA-target genes and thus risk of cancers. In this study, we investigated associations between potentially functional SNPs in the miRNA binding sites of the 3′UTR of TNFAIP2 and gastric cancer risk in a US population. METHODS: We conducted a case-control study of 301 gastric cancer patients and 313 cancer-free controls frequency-matched by age, sex and ethnicity. We genotyped four selected TNFAIP2 SNPs (rs8126 T>C, rs710100 G>A, rs1052912 G>A and rs1052823 G>T) and used the logistic regression analysis to assess associations of these SNPs with cancer risk. RESULTS: The rs8126 CC genotype was associated with a significantly elevated risk of gastric cancer (adjusted OR = 2.00, 95% CI = 1.09–3.64 and P = 0.024), compared with the combined rs8126 TT+TC genotypes, particularly in current drinkers. However, none of other TNFAIP2 SNPs was associated with risk of gastric cancer. CONCLUSIONS: Our data suggested that the TNFAIP2 miRNA binding site rs8126 T>C SNP may be a marker for susceptibility to gastric cancer, and this finding requires further validation by larger studies. Public Library of Science 2013-05-28 /pmc/articles/PMC3665554/ /pubmed/23724109 http://dx.doi.org/10.1371/journal.pone.0064973 Text en © 2013 Xu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Xu, Yu Ma, Hongxia Yu, Hongping Liu, Zhensheng Wang, Li-E Tan, Dongfeng Muddasani, Ramya Lu, Victoria Ajani, Jaffer A. Wang, Yanong Wei, Qingyi The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer |
title | The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer |
title_full | The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer |
title_fullStr | The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer |
title_full_unstemmed | The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer |
title_short | The miR-184 Binding-Site rs8126 T>C Polymorphism in TNFAIP2 Is Associated with Risk of Gastric Cancer |
title_sort | mir-184 binding-site rs8126 t>c polymorphism in tnfaip2 is associated with risk of gastric cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665554/ https://www.ncbi.nlm.nih.gov/pubmed/23724109 http://dx.doi.org/10.1371/journal.pone.0064973 |
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