Cargando…

Foxp3(+) Regulatory T Cells Are Required for Recovery from Severe Sepsis

The role of regulatory T cells (Tregs) in bacterial sepsis remains controversial because antibody-mediated depletion experiments gave conflicting results. We employed DEREG mice (DEpletion of REGulatory T cells) and a caecal ligation and puncture model to elucidate the role of CD4(+)Foxp3(+) Tregs i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kühlhorn, Franziska, Rath, Matthias, Schmoeckel, Katrin, Cziupka, Katharina, Nguyen, Huu Hung, Hildebrandt, Petra, Hünig, Thomas, Sparwasser, Tim, Huehn, Jochen, Pötschke, Christian, Bröker, Barbara M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665556/ https://www.ncbi.nlm.nih.gov/pubmed/23724126 http://dx.doi.org/10.1371/journal.pone.0065109

Ejemplares similares

Foxp3(+) Regulatory T Cells Control Persistence of Viral CNS Infection
por: Reuter, Dajana, et al.
Publicado: (2012)

Full Activation of CD4(+) T Cells Early During Sepsis Requires Specific Antigen
por: Schmoeckel, Katrin, et al.
Publicado: (2015)

Polymicrobial sepsis and non-specific immunization induce adaptive immunosuppression to a similar degree
por: Schmoeckel, Katrin, et al.
Publicado: (2018)

Advantages of Foxp3(+) regulatory T cell depletion using DEREG mice
por: Mayer, Christian T, et al.
Publicado: (2014)

Selective depletion of Foxp3(+) regulatory T cells induces a scurfy-like disease
por: Lahl, Katharina, et al.
Publicado: (2007)

Antibody Production in Murine Polymicrobial Sepsis—Kinetics and Key Players
por: Nicolai, Oliver, et al.
Publicado: (2020)

Extracellular NAD(+) shapes the Foxp3(+) regulatory T cell compartment through the ART2–P2X7 pathway
por: Hubert, Sandra, et al.
Publicado: (2010)

Generation of Foxp3(+)CD25(−) Regulatory T-Cell Precursors Requires c-Rel and IκB(NS)
por: Schuster, Marc, et al.
Publicado: (2019)

Methylation matters: binding of Ets-1 to the demethylated Foxp3 gene contributes to the stabilization of Foxp3 expression in regulatory T cells
por: Polansky, Julia K., et al.
Publicado: (2010)

Promiscuous Foxp3-cre activity reveals a differential requirement for CD28 in Foxp3(+) and Foxp3(−) T cells
por: Franckaert, Dean, et al.
Publicado: (2015)

Epigenetic Control of the foxp3 Locus in Regulatory T Cells
por: Floess, Stefan, et al.
Publicado: (2007)

Vagaries of Fluorochrome Reporter Gene Expression in Foxp3(+) Regulatory T Cells
por: Schallenberg, Sonja, et al.
Publicado: (2012)

Foxp3(+) Regulatory T Cells Delay Expulsion of Intestinal Nematodes by Suppression of IL-9-Driven Mast Cell Activation in BALB/c but Not in C57BL/6 Mice
por: Blankenhaus, Birte, et al.
Publicado: (2014)

Foxp3(+) Regulatory T Cells in Mouse Models of Type 1 Diabetes
por: Petzold, Cathleen, et al.
Publicado: (2013)

Vitamin C supports conversion of human γδ T cells into FOXP3-expressing regulatory cells by epigenetic regulation
por: Kouakanou, Léonce, et al.
Publicado: (2020)

Regulatory CD4(+)Foxp3(+) T Cells Control the Severity of Anaphylaxis
por: Kanjarawi, Reem, et al.
Publicado: (2013)

Protection of Mice from Acute Graft-versus-Host Disease Requires CD28 Co-stimulation on Donor CD4(+) Foxp3(+) Regulatory T Cells
por: Uri, Anna, et al.
Publicado: (2017)

Optimal Isolation of Functional Foxp3(+) Induced Regulatory T Cells Using DEREG Mice
por: Baru, Abdul Mannan, et al.
Publicado: (2012)

Experimental Sepsis Impairs Humoral Memory in Mice
por: Pötschke, Christian, et al.
Publicado: (2013)

Tregs in infection and vaccinology: heroes or traitors?
por: Berod, Luciana, et al.
Publicado: (2012)

Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression
por: Goldstein, Jérémie D., et al.
Publicado: (2016)

Alloantigen-Induced Regulatory T Cells Generated in Presence of Vitamin C Display Enhanced Stability of Foxp3 Expression and Promote Skin Allograft Acceptance
por: Nikolouli, Eirini, et al.
Publicado: (2017)

Mesenteric lymph node stromal cell‐derived extracellular vesicles contribute to peripheral de novo induction of Foxp3(+) regulatory T cells
por: Pasztoi, Maria, et al.
Publicado: (2017)

Development of Foxp3+ regulatory T cell: epigenetics and more…
por: Hühn, Jochen
Publicado: (2011)

FoxP3+ Regulatory T Cells Determine Disease Severity in Rodent Models of Inflammatory Neuropathies
por: Meyer zu Hörste, Gerd, et al.
Publicado: (2014)

Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation
por: Garg, Garima, et al.
Publicado: (2019)

Colon Ascendens Stent Peritonitis (CASP) - a Standardized Model for Polymicrobial Abdominal Sepsis
por: Traeger, Tobias, et al.
Publicado: (2010)

The Treg-Specific Demethylated Region Stabilizes Foxp3 Expression Independently of NF-κB Signaling
por: Schreiber, Lisa, et al.
Publicado: (2014)

Absence of Foxp3(+) Regulatory T Cells during Allergen Provocation Does Not Exacerbate Murine Allergic Airway Inflammation
por: Baru, Abdul Mannan, et al.
Publicado: (2012)

Neuropilin 1 deficiency on CD4(+)Foxp3(+) regulatory T cells impairs mouse melanoma growth
por: Hansen, Wiebke, et al.
Publicado: (2012)

Transient Depletion of Foxp3(+) Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice
por: Watts, Deepika, et al.
Publicado: (2021)

Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1
por: Bothur, Evita, et al.
Publicado: (2015)

Schistosoma mansoni-Mediated Suppression of Allergic Airway Inflammation Requires Patency and Foxp3(+) Treg Cells
por: Layland, Laura E., et al.
Publicado: (2013)

Tbx21 and Foxp3 Are Epigenetically Stabilized in T-Bet(+) Tregs That Transiently Accumulate in Influenza A Virus-Infected Lungs
por: Elfaki, Yassin, et al.
Publicado: (2021)

Next-generation insights into regulatory T cells: expression profiling and FoxP3 occupancy in Human
por: Birzele, Fabian, et al.
Publicado: (2011)

Neuropilin 1 is expressed on thymus-derived natural regulatory T cells, but not mucosa-generated induced Foxp3(+) T reg cells
por: Weiss, Jonathan M., et al.
Publicado: (2012)

Human FOXP3(+) T regulatory cell heterogeneity
por: Mohr, Audrey, et al.
Publicado: (2018)

c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells
por: Isomura, Iwao, et al.
Publicado: (2010)

c-Rel is required for the development of thymic Foxp3(+) CD4 regulatory T cells
por: Isomura, Iwao, et al.
Publicado: (2009)

The thymic medulla is required for Foxp3(+) regulatory but not conventional CD4(+) thymocyte development
por: Cowan, Jennifer E., et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_h9bljlb3e79soki3vjljdorqe9