Linking Protective GAB2 Variants, Increased Cortical GAB2 Expression and Decreased Alzheimer’s Disease Pathology

GRB-associated binding protein 2 (GAB2) represents a compelling genome-wide association signal for late-onset Alzheimer’s disease (LOAD) with reported odds ratios (ORs) ranging from 0.75–0.85. We tested eight GAB2 variants in four North American Caucasian case-control series (2,316 LOAD, 2,538 contr...

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Detalles Bibliográficos
Autores principales: Zou, Fanggeng, Belbin, Olivia, Carrasquillo, Minerva M., Culley, Oliver J., Hunter, Talisha A., Ma, Li, Bisceglio, Gina D., Allen, Mariet, Dickson, Dennis W., Graff-Radford, Neill R., Petersen, Ronald C., Morgan, Kevin, Younkin, Steven G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3665686/
https://www.ncbi.nlm.nih.gov/pubmed/23724096
http://dx.doi.org/10.1371/journal.pone.0064802

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