Challenges in the clinical development of PI3K inhibitors

The PI3K/Akt/mTOR pathway is one of the most frequently dysregulated signaling pathways in cancer and an important target for drug development. PI3K signaling plays a fundamental role in tumorigenesis, governing cell proliferation, survival, motility, and angiogenesis. Activation of the pathway is f...

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Detalles Bibliográficos
Autores principales: Massacesi, Cristian, Tomaso, Emmanuelle, Fretault, Nathalie, Hirawat, Samit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666091/
https://www.ncbi.nlm.nih.gov/pubmed/23551097
http://dx.doi.org/10.1111/nyas.12060

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666091/
https://www.ncbi.nlm.nih.gov/pubmed/23551097
http://dx.doi.org/10.1111/nyas.12060

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