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Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue

The protective effect of magnesium as magnesium sulfate (MS) on sodium-metavanadate- (SMV-) induced lipid peroxidation (LPO) under in vivo and in vitro conditions was studied. The 18-week SMV intoxication (Group II, 0.125 V(end)/mL) enhanced spontaneous malondialdehyde (MDA) generation in rat liver,...

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Autores principales: Ścibior, Agnieszka, Gołębiowska, Dorota, Niedźwiecka, Irmina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666205/
https://www.ncbi.nlm.nih.gov/pubmed/23766862
http://dx.doi.org/10.1155/2013/802734
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author Ścibior, Agnieszka
Gołębiowska, Dorota
Niedźwiecka, Irmina
author_facet Ścibior, Agnieszka
Gołębiowska, Dorota
Niedźwiecka, Irmina
author_sort Ścibior, Agnieszka
collection PubMed
description The protective effect of magnesium as magnesium sulfate (MS) on sodium-metavanadate- (SMV-) induced lipid peroxidation (LPO) under in vivo and in vitro conditions was studied. The 18-week SMV intoxication (Group II, 0.125 V(end)/mL) enhanced spontaneous malondialdehyde (MDA) generation in rat liver, compared with the control (Group I) and MS-supplemented animals (Group III, 0.06 Mg(end)/mL). Coadministration of SMV with MS (Group IV, SMV-MS) caused a return of the MDA level to the control value range. The effect seems to result from the Mg(end)-independent action and its antagonistic interaction with V(end). The in vitro treatment of liver supernatants (LS) obtained from all the tested animals groups with selected exogenous concentrations of Fe(exg) or V(exg) exhibited enhanced MDA production, compared with spontaneously formed MDA. It also showed Mg(exg)-stimulating effect on LPO (LS I, Group I) and revealed that the changes in the MDA generation in LS IV (Group IV) might have resulted from the synergistic interactions of V(end) with Fe(exg) and V(exg) and from the antagonistic interactions of Mg(end) with Fe(exg) and V(exg). The findings allow a suggestion that adequate Mg intake for a specific period in the conditions of SMV exposure may prevent V-induced LPO in the liver.
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spelling pubmed-36662052013-06-13 Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue Ścibior, Agnieszka Gołębiowska, Dorota Niedźwiecka, Irmina Oxid Med Cell Longev Research Article The protective effect of magnesium as magnesium sulfate (MS) on sodium-metavanadate- (SMV-) induced lipid peroxidation (LPO) under in vivo and in vitro conditions was studied. The 18-week SMV intoxication (Group II, 0.125 V(end)/mL) enhanced spontaneous malondialdehyde (MDA) generation in rat liver, compared with the control (Group I) and MS-supplemented animals (Group III, 0.06 Mg(end)/mL). Coadministration of SMV with MS (Group IV, SMV-MS) caused a return of the MDA level to the control value range. The effect seems to result from the Mg(end)-independent action and its antagonistic interaction with V(end). The in vitro treatment of liver supernatants (LS) obtained from all the tested animals groups with selected exogenous concentrations of Fe(exg) or V(exg) exhibited enhanced MDA production, compared with spontaneously formed MDA. It also showed Mg(exg)-stimulating effect on LPO (LS I, Group I) and revealed that the changes in the MDA generation in LS IV (Group IV) might have resulted from the synergistic interactions of V(end) with Fe(exg) and V(exg) and from the antagonistic interactions of Mg(end) with Fe(exg) and V(exg). The findings allow a suggestion that adequate Mg intake for a specific period in the conditions of SMV exposure may prevent V-induced LPO in the liver. Hindawi Publishing Corporation 2013 2013-05-13 /pmc/articles/PMC3666205/ /pubmed/23766862 http://dx.doi.org/10.1155/2013/802734 Text en Copyright © 2013 Agnieszka Ścibior et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ścibior, Agnieszka
Gołębiowska, Dorota
Niedźwiecka, Irmina
Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue
title Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue
title_full Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue
title_fullStr Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue
title_full_unstemmed Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue
title_short Magnesium Can Protect against Vanadium-Induced Lipid Peroxidation in the Hepatic Tissue
title_sort magnesium can protect against vanadium-induced lipid peroxidation in the hepatic tissue
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666205/
https://www.ncbi.nlm.nih.gov/pubmed/23766862
http://dx.doi.org/10.1155/2013/802734
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