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Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models
Acupuncture and electroacupuncture (EA) are widely used to treat a variety of diseases including pain. In preclinical research, EA is usually applied by inserting acupuncture needles into the hindlimbs of rats restrained in small tubes or bags. This restrained model of EA not only causes stress-like...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666275/ https://www.ncbi.nlm.nih.gov/pubmed/23737830 http://dx.doi.org/10.1155/2013/404956 |
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author | Zhang, Haolin Chen, Xiaolong Zhang, Chan Zhang, Ruixin Lao, Lixing Wan, You Yi, Ming |
author_facet | Zhang, Haolin Chen, Xiaolong Zhang, Chan Zhang, Ruixin Lao, Lixing Wan, You Yi, Ming |
author_sort | Zhang, Haolin |
collection | PubMed |
description | Acupuncture and electroacupuncture (EA) are widely used to treat a variety of diseases including pain. In preclinical research, EA is usually applied by inserting acupuncture needles into the hindlimbs of rats restrained in small tubes or bags. This restrained model of EA not only causes stress-like behaviors but also is limited in stimulating locations and intensities. In 2004, a novel, unrestrained model of EA was introduced. However, these two EA methods have never been directly compared regarding their analgesic effects and other features such as stress. In the present study, we reported similar analgesic effects between restrained and unrestrained EA in rats of acute inflammatory pain induced by intraplantar injection of CFA. In addition, rats receiving unrestrained EA showed less significant stress-like behaviors and tolerated higher current intensity. These advantages suggest that this unrestrained EA method can replace the traditional restrained procedure with similar analgesic effects and allow for more choices of stimulating intensities and locations. |
format | Online Article Text |
id | pubmed-3666275 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-36662752013-06-04 Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models Zhang, Haolin Chen, Xiaolong Zhang, Chan Zhang, Ruixin Lao, Lixing Wan, You Yi, Ming Evid Based Complement Alternat Med Research Article Acupuncture and electroacupuncture (EA) are widely used to treat a variety of diseases including pain. In preclinical research, EA is usually applied by inserting acupuncture needles into the hindlimbs of rats restrained in small tubes or bags. This restrained model of EA not only causes stress-like behaviors but also is limited in stimulating locations and intensities. In 2004, a novel, unrestrained model of EA was introduced. However, these two EA methods have never been directly compared regarding their analgesic effects and other features such as stress. In the present study, we reported similar analgesic effects between restrained and unrestrained EA in rats of acute inflammatory pain induced by intraplantar injection of CFA. In addition, rats receiving unrestrained EA showed less significant stress-like behaviors and tolerated higher current intensity. These advantages suggest that this unrestrained EA method can replace the traditional restrained procedure with similar analgesic effects and allow for more choices of stimulating intensities and locations. Hindawi Publishing Corporation 2013 2013-05-12 /pmc/articles/PMC3666275/ /pubmed/23737830 http://dx.doi.org/10.1155/2013/404956 Text en Copyright © 2013 Haolin Zhang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Zhang, Haolin Chen, Xiaolong Zhang, Chan Zhang, Ruixin Lao, Lixing Wan, You Yi, Ming Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models |
title | Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models |
title_full | Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models |
title_fullStr | Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models |
title_full_unstemmed | Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models |
title_short | Comparison of Electroacupuncture in Restrained and Unrestrained Rat Models |
title_sort | comparison of electroacupuncture in restrained and unrestrained rat models |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666275/ https://www.ncbi.nlm.nih.gov/pubmed/23737830 http://dx.doi.org/10.1155/2013/404956 |
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