Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study

This prospective randomized study is to evaluate the locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective nodal irradiation (ENI) in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer. It appears that high...

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Autores principales: Chen, Ming, Bao, Yong, Ma, Hong-Lian, Hu, Xiao, Wang, Jin, Wang, Yan, Peng, Fang, Zhou, Qi-Chao, Xie, Cong-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Clinical Study
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666303/
https://www.ncbi.nlm.nih.gov/pubmed/23762840
http://dx.doi.org/10.1155/2013/371819
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author Chen, Ming
Bao, Yong
Ma, Hong-Lian
Hu, Xiao
Wang, Jin
Wang, Yan
Peng, Fang
Zhou, Qi-Chao
Xie, Cong-Hua
author_facet Chen, Ming
Bao, Yong
Ma, Hong-Lian
Hu, Xiao
Wang, Jin
Wang, Yan
Peng, Fang
Zhou, Qi-Chao
Xie, Cong-Hua
author_sort Chen, Ming
collection PubMed
description This prospective randomized study is to evaluate the locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective nodal irradiation (ENI) in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer. It appears that higher dose could be delivered in IFRT arm than that in ENI arm, and IFRT did not increase the risk of initially uninvolved or isolated nodal failures. Both a tendency of improved locoregional progression-free survival and a significant increased overall survival rate are in favor of IFRT arm in this study.
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spelling pubmed-36663032013-06-12 Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study Chen, Ming Bao, Yong Ma, Hong-Lian Hu, Xiao Wang, Jin Wang, Yan Peng, Fang Zhou, Qi-Chao Xie, Cong-Hua Biomed Res Int Clinical Study This prospective randomized study is to evaluate the locoregional failure and its impact on survival by comparing involved field radiotherapy (IFRT) with elective nodal irradiation (ENI) in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer. It appears that higher dose could be delivered in IFRT arm than that in ENI arm, and IFRT did not increase the risk of initially uninvolved or isolated nodal failures. Both a tendency of improved locoregional progression-free survival and a significant increased overall survival rate are in favor of IFRT arm in this study. Hindawi Publishing Corporation 2013 2013-05-13 /pmc/articles/PMC3666303/ /pubmed/23762840 http://dx.doi.org/10.1155/2013/371819 Text en Copyright © 2013 Ming Chen et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Chen, Ming
Bao, Yong
Ma, Hong-Lian
Hu, Xiao
Wang, Jin
Wang, Yan
Peng, Fang
Zhou, Qi-Chao
Xie, Cong-Hua
Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study
title Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study
title_full Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study
title_fullStr Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study
title_full_unstemmed Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study
title_short Involved-Field Radiotherapy versus Elective Nodal Irradiation in Combination with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Prospective Randomized Study
title_sort involved-field radiotherapy versus elective nodal irradiation in combination with concurrent chemotherapy for locally advanced non-small cell lung cancer: a prospective randomized study
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666303/
https://www.ncbi.nlm.nih.gov/pubmed/23762840
http://dx.doi.org/10.1155/2013/371819
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