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Lamin A/C and emerin regulate MKL1/SRF activity by modulating actin dynamics

Laminopathies, caused by mutations in the LMNA gene encoding the nuclear envelope proteins lamins A and C, represent a diverse group of diseases that include Emery-Dreifuss Muscular Dystrophy (EDMD), dilated cardiomyopathy (DCM), limb-girdle muscular dystrophy, and Hutchison-Gilford progeria syndrom...

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Detalles Bibliográficos
Autores principales: Ho, Chin Yee, Jaalouk, Diana E., Vartiainen, Maria K., Lammerding, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666313/
https://www.ncbi.nlm.nih.gov/pubmed/23644458
http://dx.doi.org/10.1038/nature12105