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Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits

The aim of this study was to investigate potential hypoglycaemic and hypolipidemic effects of Plantago ovata husk included in the diet, in healthy and diabetic rabbits. We also examined the effects of this fiber in other biochemical parameters. Two groups of 18 rabbits were used. The first group was...

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Autores principales: Díez, Raquel, García, Juan J., Diez, M. José, Sierra, Matilde, Sahagún, Ana M., Calle, Ángela P., Fernández, Nélida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666357/
https://www.ncbi.nlm.nih.gov/pubmed/23762869
http://dx.doi.org/10.1155/2013/960568
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author Díez, Raquel
García, Juan J.
Diez, M. José
Sierra, Matilde
Sahagún, Ana M.
Calle, Ángela P.
Fernández, Nélida
author_facet Díez, Raquel
García, Juan J.
Diez, M. José
Sierra, Matilde
Sahagún, Ana M.
Calle, Ángela P.
Fernández, Nélida
author_sort Díez, Raquel
collection PubMed
description The aim of this study was to investigate potential hypoglycaemic and hypolipidemic effects of Plantago ovata husk included in the diet, in healthy and diabetic rabbits. We also examined the effects of this fiber in other biochemical parameters. Two groups of 18 rabbits were used. The first group was fed with standard chow and the second with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). On day 14 diabetes mellitus was induced by the intravenous administration of alloxan (80 mg/kg). After an oral glucose load (3 g), glucose, insulin, and other biochemical parameters were determined on day 14 (healthy rabbits) and on day 28 (diabetic rabbits). In healthy rabbits, fiber did not modify glucose or insulin levels but decreased significantly total cholesterol, LDL-cholesterol, atherogenic index, and glycosylated hemoglobin. In diabetic rabbits, fiber was more beneficial in mild diabetics than in severe diabetics with significant decreases in glucose levels and increases in insulin concentrations. In these animals fiber caused an important reduction in cholesterol, indicating a beneficial effect of Plantago ovata husk in diabetic rabbits. Although further studies in patients are necessary, we think that Plantago ovata husk offers interesting perspectives to be administered to patients with diabetes mellitus.
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spelling pubmed-36663572013-06-12 Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits Díez, Raquel García, Juan J. Diez, M. José Sierra, Matilde Sahagún, Ana M. Calle, Ángela P. Fernández, Nélida Biomed Res Int Research Article The aim of this study was to investigate potential hypoglycaemic and hypolipidemic effects of Plantago ovata husk included in the diet, in healthy and diabetic rabbits. We also examined the effects of this fiber in other biochemical parameters. Two groups of 18 rabbits were used. The first group was fed with standard chow and the second with chow supplemented with Plantago ovata husk (3.5 mg/kg/day). On day 14 diabetes mellitus was induced by the intravenous administration of alloxan (80 mg/kg). After an oral glucose load (3 g), glucose, insulin, and other biochemical parameters were determined on day 14 (healthy rabbits) and on day 28 (diabetic rabbits). In healthy rabbits, fiber did not modify glucose or insulin levels but decreased significantly total cholesterol, LDL-cholesterol, atherogenic index, and glycosylated hemoglobin. In diabetic rabbits, fiber was more beneficial in mild diabetics than in severe diabetics with significant decreases in glucose levels and increases in insulin concentrations. In these animals fiber caused an important reduction in cholesterol, indicating a beneficial effect of Plantago ovata husk in diabetic rabbits. Although further studies in patients are necessary, we think that Plantago ovata husk offers interesting perspectives to be administered to patients with diabetes mellitus. Hindawi Publishing Corporation 2013 2013-05-14 /pmc/articles/PMC3666357/ /pubmed/23762869 http://dx.doi.org/10.1155/2013/960568 Text en Copyright © 2013 Raquel Díez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Díez, Raquel
García, Juan J.
Diez, M. José
Sierra, Matilde
Sahagún, Ana M.
Calle, Ángela P.
Fernández, Nélida
Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits
title Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits
title_full Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits
title_fullStr Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits
title_full_unstemmed Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits
title_short Hypoglycemic and Hypolipidemic Potential of a High Fiber Diet in Healthy versus Diabetic Rabbits
title_sort hypoglycemic and hypolipidemic potential of a high fiber diet in healthy versus diabetic rabbits
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666357/
https://www.ncbi.nlm.nih.gov/pubmed/23762869
http://dx.doi.org/10.1155/2013/960568
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