Cargando…

Hierarchical Organization of Multi-Site Phosphorylation at the CXCR4 C Terminus

The chemokine receptor CXCR4 regulates cell migration during ontogenesis and disease states including cancer and inflammation. Upon stimulation by the endogenous ligand CXCL12, CXCR4 becomes phosphorylated at multiple sites in its C-terminal domain. Mutations in the CXCR4 gene affecting C-terminal p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mueller, Wiebke, Schütz, Dagmar, Nagel, Falko, Schulz, Stefan, Stumm, Ralf
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666969/ https://www.ncbi.nlm.nih.gov/pubmed/23734232 http://dx.doi.org/10.1371/journal.pone.0064975

Ejemplares similares

Reassessment of CXCR4 Chemokine Receptor Expression in Human Normal and Neoplastic Tissues Using the Novel Rabbit Monoclonal Antibody UMB-2
por: Fischer, Thomas, et al.
Publicado: (2008)

CXC Chemokine Receptor 7 (CXCR7) Regulates CXCR4 Protein Expression and Capillary Tuft Development in Mouse Kidney
por: Haege, Sammy, et al.
Publicado: (2012)

The microcephaly gene Donson is essential for progenitors of cortical glutamatergic and GABAergic neurons
por: Venkataramanappa, Sathish, et al.
Publicado: (2021)

Individual phosphorylation sites at the C-terminus of the apelin receptor play different roles in signal transduction
por: Chen, Jing, et al.
Publicado: (2020)

Critical residues in the PMEL/Pmel17 N-terminus direct the hierarchical assembly of melanosomal fibrils
por: Leonhardt, Ralf M., et al.
Publicado: (2013)

The N-terminus of CXCR4 splice variants determines expression and functional properties
por: Park, Hee-Kyung, et al.
Publicado: (2023)

Influence of a GSK3β phosphorylation site within the proximal C-terminus of Neurofilament-H on neurofilament dynamics
por: Vohnoutka, Rishel Brenna, et al.
Publicado: (2017)

Single‐residue posttranslational modification sites at the N‐terminus, C‐terminus or in‐between: To be or not to be exposed for enzyme access
por: Sirota, Fernanda L., et al.
Publicado: (2015)

Phosphorylation of the RB C-terminus regulates condensin II release from chromatin
por: Kim, Seung J., et al.
Publicado: (2020)

90K Glycoprotein Promotes Degradation of Mutant β-Catenin Lacking the ISGylation or Phosphorylation Sites in the N-terminus()()
por: Park, So-Yeon, et al.
Publicado: (2016)

Melanopsin Carboxy-terminus phosphorylation plasticity and bulk negative charge, not strict site specificity, achieves phototransduction deactivation
por: Valdez-Lopez, Juan C., et al.
Publicado: (2020)

Two adjacent phosphorylation sites in the C-terminus of the channel’s α-subunit have opposing effects on epithelial sodium channel (ENaC) activity
por: Diakov, Alexei, et al.
Publicado: (2022)

Dual role for CXCL12 signaling in semilunar valve development
por: Ridge, Liam A., et al.
Publicado: (2021)

Correction to: Two adjacent phosphorylation sites in the C-terminus of the channel’s α-subunit have opposing effects on epithelial sodium channel (ENaC) activity
por: Diakov, Alexei, et al.
Publicado: (2022)

Exploiting Protein N-Terminus for Site-Specific Bioconjugation
por: De Rosa, Lucia, et al.
Publicado: (2021)

Mitotic Phosphorylation of TREX1 C Terminus Disrupts TREX1 Regulation of the Oligosaccharyltransferase Complex
por: Kucej, Martin, et al.
Publicado: (2017)

Lineage Analysis of Cxcr4-Expressing Cells in the Developing Midbrain Suggests That Progressive Competence Restriction in Dopaminergic Progenitor Cells Contributes to the Establishment of Dopaminergic Neuronal Diversity
por: Petese, Alessandro, et al.
Publicado: (2022)

Multi-Organ Contribution to the Metabolic Plasma Profile Using Hierarchical Modelling
por: Torell, Frida, et al.
Publicado: (2015)

Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate
por: Ruff, Crystal A, et al.
Publicado: (2012)

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease
por: Flores-Rodríguez, Paola, et al.
Publicado: (2015)

Phosphorylation of the BNIP3 C-Terminus Inhibits Mitochondrial Damage and Cell Death without Blocking Autophagy
por: Liu, Katherine E., et al.
Publicado: (2015)

Kinetics of the Interactions between Copper and Amyloid‐β with FAD Mutations and Phosphorylation at the N terminus
por: Girvan, Paul, et al.
Publicado: (2016)

Cx43 Channel Gating and Permeation: Multiple Phosphorylation-Dependent Roles of the Carboxyl Terminus
por: Ek-Vitorín, José F., et al.
Publicado: (2018)

The N-terminus of the prion protein is a toxic effector regulated by the C-terminus
por: Wu, Bei, et al.
Publicado: (2017)

Characterization of the S100A1 Protein Binding Site on TRPC6 C-Terminus
por: Bily, Jan, et al.
Publicado: (2013)

A mechanism for exocytotic arrest by the Complexin C-terminus
por: Makke, Mazen, et al.
Publicado: (2018)

Phosphorylation barcodes direct biased chemokine signaling at CXCR3
por: Eiger, Dylan S., et al.
Publicado: (2023)

Selective phosphorylation of threonine residues defines GPR84–arrestin interactions of biased ligands
por: Marsango, Sara, et al.
Publicado: (2022)

Sequence terminus dependent PCR for site-specific mutation and modification detection
por: Xu, Gaolian, et al.
Publicado: (2023)

Phosphorylation of the amino-terminus of the AGC kinase Gad8 prevents its interaction with TORC2
por: Du, Wei, et al.
Publicado: (2016)

Phosphorylation-Dependent Intra-Domain Interaction of the Cx37 Carboxyl-Terminus Controls Cell Survival
por: Jacobsen, Nicole L., et al.
Publicado: (2019)

S92 phosphorylation induces structural changes in the N-terminus domain of human mitochondrial calcium uniporter
por: Lee, Youngjin, et al.
Publicado: (2020)

Bioinformatic Analysis of Na(+), K(+)-ATPase Regulation through Phosphorylation of the Alpha-Subunit N-Terminus
por: Blayney, Emma-Lucille, et al.
Publicado: (2022)

Site-Selective C(sp(3))–H Functionalization of Di-, Tri-, and Tetrapeptides at the N-Terminus
por: Gong, Wei, et al.
Publicado: (2014)

The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus
por: Byrne, Ashleigh M., et al.
Publicado: (2015)

Connexin 43 overexpression induces lung cancer angiogenesis in vitro following phosphorylation at Ser279 in its C-terminus
por: Zhou, Zizi, et al.
Publicado: (2022)

Streptophyte phytochromes exhibit an N-terminus of cyanobacterial origin and a C-terminus of proteobacterial origin
por: Buchberger, Thorsten, et al.
Publicado: (2015)

Albumin Fusion at the N-Terminus or C-Terminus of HM-3 Leads to Improved Pharmacokinetics and Bioactivities
por: Li, Ting, et al.
Publicado: (2021)

Hierarchical covalent organic framework-foam for multi-enzyme tandem catalysis
por: Paul, Satyadip, et al.
Publicado: (2023)

The Phosphorylation of CCR6 on Distinct Ser/Thr Residues in the Carboxyl Terminus Differentially Regulates Biological Function
por: Lu, Mei-Yi, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7vftmv76llt5l8t66ptbvjg782