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Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6
Autism Spectrum Disorder (ASD) is a developmental disability that affects social behavior and language acquisition. ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heteroge...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666972/ https://www.ncbi.nlm.nih.gov/pubmed/23734230 http://dx.doi.org/10.1371/journal.pone.0064967 |
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author | Kuhl, Patricia K. Coffey-Corina, Sharon Padden, Denise Munson, Jeffrey Estes, Annette Dawson, Geraldine |
author_facet | Kuhl, Patricia K. Coffey-Corina, Sharon Padden, Denise Munson, Jeffrey Estes, Annette Dawson, Geraldine |
author_sort | Kuhl, Patricia K. |
collection | PubMed |
description | Autism Spectrum Disorder (ASD) is a developmental disability that affects social behavior and language acquisition. ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heterogeneity in autism and serves as a modest predictor of later function. We show that a brain measure (event-related potentials, ERPs) of word processing in children with ASD, assessed at the age of 2 years (N = 24), is a broad and robust predictor of receptive language, cognitive ability, and adaptive behavior at ages 4 and 6 years, regardless of the form of intensive clinical treatment during the intervening years. The predictive strength of this brain measure increases over time, and exceeds the predictive strength of a measure of cognitive ability, used here for comparison. These findings have theoretical implications and may eventually lead to neural measures that allow early prediction of developmental outcomes as well as more individually tailored clinical interventions, with the potential for greater effectiveness in treating children with ASD. |
format | Online Article Text |
id | pubmed-3666972 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36669722013-06-03 Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6 Kuhl, Patricia K. Coffey-Corina, Sharon Padden, Denise Munson, Jeffrey Estes, Annette Dawson, Geraldine PLoS One Research Article Autism Spectrum Disorder (ASD) is a developmental disability that affects social behavior and language acquisition. ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heterogeneity in autism and serves as a modest predictor of later function. We show that a brain measure (event-related potentials, ERPs) of word processing in children with ASD, assessed at the age of 2 years (N = 24), is a broad and robust predictor of receptive language, cognitive ability, and adaptive behavior at ages 4 and 6 years, regardless of the form of intensive clinical treatment during the intervening years. The predictive strength of this brain measure increases over time, and exceeds the predictive strength of a measure of cognitive ability, used here for comparison. These findings have theoretical implications and may eventually lead to neural measures that allow early prediction of developmental outcomes as well as more individually tailored clinical interventions, with the potential for greater effectiveness in treating children with ASD. Public Library of Science 2013-05-29 /pmc/articles/PMC3666972/ /pubmed/23734230 http://dx.doi.org/10.1371/journal.pone.0064967 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. |
spellingShingle | Research Article Kuhl, Patricia K. Coffey-Corina, Sharon Padden, Denise Munson, Jeffrey Estes, Annette Dawson, Geraldine Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6 |
title | Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6 |
title_full | Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6 |
title_fullStr | Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6 |
title_full_unstemmed | Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6 |
title_short | Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6 |
title_sort | brain responses to words in 2-year-olds with autism predict developmental outcomes at age 6 |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666972/ https://www.ncbi.nlm.nih.gov/pubmed/23734230 http://dx.doi.org/10.1371/journal.pone.0064967 |
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