Cargando…

Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6

Autism Spectrum Disorder (ASD) is a developmental disability that affects social behavior and language acquisition. ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heteroge...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuhl, Patricia K., Coffey-Corina, Sharon, Padden, Denise, Munson, Jeffrey, Estes, Annette, Dawson, Geraldine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666972/
https://www.ncbi.nlm.nih.gov/pubmed/23734230
http://dx.doi.org/10.1371/journal.pone.0064967
_version_ 1782271415392665600
author Kuhl, Patricia K.
Coffey-Corina, Sharon
Padden, Denise
Munson, Jeffrey
Estes, Annette
Dawson, Geraldine
author_facet Kuhl, Patricia K.
Coffey-Corina, Sharon
Padden, Denise
Munson, Jeffrey
Estes, Annette
Dawson, Geraldine
author_sort Kuhl, Patricia K.
collection PubMed
description Autism Spectrum Disorder (ASD) is a developmental disability that affects social behavior and language acquisition. ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heterogeneity in autism and serves as a modest predictor of later function. We show that a brain measure (event-related potentials, ERPs) of word processing in children with ASD, assessed at the age of 2 years (N = 24), is a broad and robust predictor of receptive language, cognitive ability, and adaptive behavior at ages 4 and 6 years, regardless of the form of intensive clinical treatment during the intervening years. The predictive strength of this brain measure increases over time, and exceeds the predictive strength of a measure of cognitive ability, used here for comparison. These findings have theoretical implications and may eventually lead to neural measures that allow early prediction of developmental outcomes as well as more individually tailored clinical interventions, with the potential for greater effectiveness in treating children with ASD.
format Online
Article
Text
id pubmed-3666972
institution National Center for Biotechnology Information
language English
publishDate 2013
publisher Public Library of Science
record_format MEDLINE/PubMed
spelling pubmed-36669722013-06-03 Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6 Kuhl, Patricia K. Coffey-Corina, Sharon Padden, Denise Munson, Jeffrey Estes, Annette Dawson, Geraldine PLoS One Research Article Autism Spectrum Disorder (ASD) is a developmental disability that affects social behavior and language acquisition. ASD exhibits great variability in outcomes, with some individuals remaining nonverbal and others exhibiting average or above average function. Cognitive ability contributes to heterogeneity in autism and serves as a modest predictor of later function. We show that a brain measure (event-related potentials, ERPs) of word processing in children with ASD, assessed at the age of 2 years (N = 24), is a broad and robust predictor of receptive language, cognitive ability, and adaptive behavior at ages 4 and 6 years, regardless of the form of intensive clinical treatment during the intervening years. The predictive strength of this brain measure increases over time, and exceeds the predictive strength of a measure of cognitive ability, used here for comparison. These findings have theoretical implications and may eventually lead to neural measures that allow early prediction of developmental outcomes as well as more individually tailored clinical interventions, with the potential for greater effectiveness in treating children with ASD. Public Library of Science 2013-05-29 /pmc/articles/PMC3666972/ /pubmed/23734230 http://dx.doi.org/10.1371/journal.pone.0064967 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle Research Article
Kuhl, Patricia K.
Coffey-Corina, Sharon
Padden, Denise
Munson, Jeffrey
Estes, Annette
Dawson, Geraldine
Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6
title Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6
title_full Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6
title_fullStr Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6
title_full_unstemmed Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6
title_short Brain Responses to Words in 2-Year-Olds with Autism Predict Developmental Outcomes at Age 6
title_sort brain responses to words in 2-year-olds with autism predict developmental outcomes at age 6
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3666972/
https://www.ncbi.nlm.nih.gov/pubmed/23734230
http://dx.doi.org/10.1371/journal.pone.0064967
work_keys_str_mv AT kuhlpatriciak brainresponsestowordsin2yearoldswithautismpredictdevelopmentaloutcomesatage6
AT coffeycorinasharon brainresponsestowordsin2yearoldswithautismpredictdevelopmentaloutcomesatage6
AT paddendenise brainresponsestowordsin2yearoldswithautismpredictdevelopmentaloutcomesatage6
AT munsonjeffrey brainresponsestowordsin2yearoldswithautismpredictdevelopmentaloutcomesatage6
AT estesannette brainresponsestowordsin2yearoldswithautismpredictdevelopmentaloutcomesatage6
AT dawsongeraldine brainresponsestowordsin2yearoldswithautismpredictdevelopmentaloutcomesatage6