Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection

Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center...

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Detalles Bibliográficos
Autores principales: Desrochers, Dan, González-Peralta, Regino P., McClenathan, Daniel T., Wilsey, Michael J., Haafiz, Allah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Libertas Academica 2011
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667043/
https://www.ncbi.nlm.nih.gov/pubmed/23761995
http://dx.doi.org/10.4137/CMPed.S6406
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author Desrochers, Dan
González-Peralta, Regino P.
McClenathan, Daniel T.
Wilsey, Michael J.
Haafiz, Allah
author_facet Desrochers, Dan
González-Peralta, Regino P.
McClenathan, Daniel T.
Wilsey, Michael J.
Haafiz, Allah
author_sort Desrochers, Dan
collection PubMed
description Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children.
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spelling pubmed-36670432013-06-12 Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection Desrochers, Dan González-Peralta, Regino P. McClenathan, Daniel T. Wilsey, Michael J. Haafiz, Allah Clin Med Insights Pediatr Case Report Isoniazid (INH) monotherapy has gained widespread acceptance as an efficacious therapy for latent tuberculosis infection (LTBI) especially in low-prevalence settings. Although INH related hepatotoxicity is well recognized, progression to severe liver dysfunction requiring care at a transplant center remains unpredictable. We report the management of a five year-old girl who developed progressive liver failure due to INH prophylaxis. This highlights the potential severity of INH related hepatic injury and underscores the significance of vigilant clinical monitoring throughout the duration of the therapy in children. Libertas Academica 2011-03-23 /pmc/articles/PMC3667043/ /pubmed/23761995 http://dx.doi.org/10.4137/CMPed.S6406 Text en © 2011 the author(s), publisher and licensee Libertas Academica Ltd. This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited.
spellingShingle Case Report
Desrochers, Dan
González-Peralta, Regino P.
McClenathan, Daniel T.
Wilsey, Michael J.
Haafiz, Allah
Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection
title Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection
title_full Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection
title_fullStr Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection
title_full_unstemmed Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection
title_short Isoniazid-Induced Severe Hepatotoxicity: An Infrequent but Preventable Cause of Liver Failure in Children Treated for Latent Tuberculosis Infection
title_sort isoniazid-induced severe hepatotoxicity: an infrequent but preventable cause of liver failure in children treated for latent tuberculosis infection
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667043/
https://www.ncbi.nlm.nih.gov/pubmed/23761995
http://dx.doi.org/10.4137/CMPed.S6406
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