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Insights into the Folding and Unfolding Processes of Wild-Type and Mutated SH3 Domain by Molecular Dynamics and Replica Exchange Molecular Dynamics Simulations

Src-homology regions 3 (SH3) domain is essential for the down-regulation of tyrosine kinase activity. Mutation A39V/N53P/V55L of SH3 is found to be relative to the urgent misfolding diseases. To gain insight, the human and gallus SH3 domains (PDB ID: 1NYG and 2LP5), including 58 amino acids in each...

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Detalles Bibliográficos
Autores principales:	Chu, Wen-Ting, Zhang, Ji-Long, Zheng, Qing-Chuan, Chen, Lin, Zhang, Hong-Xing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667132/ https://www.ncbi.nlm.nih.gov/pubmed/23734224 http://dx.doi.org/10.1371/journal.pone.0064886

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