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Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective
Manufacturers have developed prototype cigarettes yielding reduced levels of some tobacco smoke toxicants, when tested using laboratory machine smoking under standardised conditions. For the scientific assessment of modified risk tobacco products, tests that offer objective, reproducible data, which...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Informa UK, Ltd.
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667677/ https://www.ncbi.nlm.nih.gov/pubmed/23530763 http://dx.doi.org/10.3109/1354750X.2013.777116 |
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author | Lowe, Frazer J. Luettich, Karsta Gregg, Evan O. |
author_facet | Lowe, Frazer J. Luettich, Karsta Gregg, Evan O. |
author_sort | Lowe, Frazer J. |
collection | PubMed |
description | Manufacturers have developed prototype cigarettes yielding reduced levels of some tobacco smoke toxicants, when tested using laboratory machine smoking under standardised conditions. For the scientific assessment of modified risk tobacco products, tests that offer objective, reproducible data, which can be obtained in a much shorter time than the requirements of conventional epidemiology are needed. In this review, we consider whether biomarkers of biological effect related to oxidative stress can be used in this role. Based on published data, urinary 8-oxo-7,8-dihydro-2-deoxyguanosine, thymidine glycol, F(2)-isoprostanes, serum dehydroascorbic acid to ascorbic acid ratio and carotenoid concentrations show promise, while 4-hydroxynonenal requires further qualification. |
format | Online Article Text |
id | pubmed-3667677 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Informa UK, Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-36676772013-05-31 Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective Lowe, Frazer J. Luettich, Karsta Gregg, Evan O. Biomarkers Review Article Manufacturers have developed prototype cigarettes yielding reduced levels of some tobacco smoke toxicants, when tested using laboratory machine smoking under standardised conditions. For the scientific assessment of modified risk tobacco products, tests that offer objective, reproducible data, which can be obtained in a much shorter time than the requirements of conventional epidemiology are needed. In this review, we consider whether biomarkers of biological effect related to oxidative stress can be used in this role. Based on published data, urinary 8-oxo-7,8-dihydro-2-deoxyguanosine, thymidine glycol, F(2)-isoprostanes, serum dehydroascorbic acid to ascorbic acid ratio and carotenoid concentrations show promise, while 4-hydroxynonenal requires further qualification. Informa UK, Ltd. 2013-05 2013-03-27 /pmc/articles/PMC3667677/ /pubmed/23530763 http://dx.doi.org/10.3109/1354750X.2013.777116 Text en © 2013 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the source is credited. |
spellingShingle | Review Article Lowe, Frazer J. Luettich, Karsta Gregg, Evan O. Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective |
title | Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective |
title_full | Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective |
title_fullStr | Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective |
title_full_unstemmed | Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective |
title_short | Lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective |
title_sort | lung cancer biomarkers for the assessment of modified risk tobacco products: an oxidative stress perspective |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667677/ https://www.ncbi.nlm.nih.gov/pubmed/23530763 http://dx.doi.org/10.3109/1354750X.2013.777116 |
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