Trafficking of the Menkes copper transporter ATP7A is regulated by clathrin-, AP-2–, AP-1–, and Rab22-dependent steps

The transporter ATP7A mediates systemic copper absorption and provides cuproenzymes in the trans-Golgi network (TGN) with copper. To regulate metal homeostasis, ATP7A constitutively cycles between the TGN and plasma membrane (PM). ATP7A trafficking to the PM is elevated in response to increased copp...

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Detalles Bibliográficos
Autores principales: Holloway, Zoe G., Velayos-Baeza, Antonio, Howell, Gareth J., Levecque, Clotilde, Ponnambalam, Sreenivasan, Sztul, Elizabeth, Monaco, Anthony P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2013
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667726/
https://www.ncbi.nlm.nih.gov/pubmed/23596324
http://dx.doi.org/10.1091/mbc.E12-08-0625

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