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A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation

During endoplasmic reticulum–associated degradation (ERAD), misfolded lumenal and membrane proteins in the ER are recognized by the transmembrane Hrd1 ubiquitin ligase complex and retrotranslocated to the cytosol for ubiquitination and degradation. Although substrates are believed to be delivered to...

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Detalles Bibliográficos
Autores principales:	Nakatsukasa, Kunio, Brodsky, Jeffrey L., Kamura, Takumi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Cell Biology 2013
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667728/ https://www.ncbi.nlm.nih.gov/pubmed/23536702 http://dx.doi.org/10.1091/mbc.E12-12-0907

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