CDK4 T172 Phosphorylation Is Central in a CDK7-Dependent Bidirectional CDK4/CDK2 Interplay Mediated by p21 Phosphorylation at the Restriction Point

Cell cycle progression, including genome duplication, is orchestrated by cyclin-dependent kinases (CDKs). CDK activation depends on phosphorylation of their T-loop by a CDK–activating kinase (CAK). In animals, the only known CAK for CDK2 and CDK1 is cyclin H-CDK7, which is constitutively active. The...

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Detalles Bibliográficos
Autores principales: Bisteau, Xavier, Paternot, Sabine, Colleoni, Bianca, Ecker, Karin, Coulonval, Katia, De Groote, Philippe, Declercq, Wim, Hengst, Ludger, Roger, Pierre P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667761/
https://www.ncbi.nlm.nih.gov/pubmed/23737759
http://dx.doi.org/10.1371/journal.pgen.1003546

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