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Conserved Inhibitory Mechanism and Competent ATP Binding Mode for Adenylyltransferases with Fic Fold

The ubiquitous FIC domain is evolutionarily conserved from bacteria to human and has been shown to catalyze AMP transfer onto protein side-chain hydroxyl groups. Recently, it was predicted that most catalytically competent Fic proteins are inhibited by the presence of an inhibitory helix α(inh) that...

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Detalles Bibliográficos
Autores principales: Goepfert, Arnaud, Stanger, Frédéric V., Dehio, Christoph, Schirmer, Tilman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667792/
https://www.ncbi.nlm.nih.gov/pubmed/23738009
http://dx.doi.org/10.1371/journal.pone.0064901

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