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Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin
Secretin (SCT) is a classical peptide hormone that is synthesized and released from the gastrointestinal tract after a meal. We have previously shown that it acts both as a central and peripheral anorectic peptide, and that its central effect is mediated via melanocortin system. As peripheral satiet...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667839/ https://www.ncbi.nlm.nih.gov/pubmed/23738005 http://dx.doi.org/10.1371/journal.pone.0064859 |
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author | Chu, Jessica Y. S. Cheng, Carrie Y. Y. Sekar, Revathi Chow, Billy K. C. |
author_facet | Chu, Jessica Y. S. Cheng, Carrie Y. Y. Sekar, Revathi Chow, Billy K. C. |
author_sort | Chu, Jessica Y. S. |
collection | PubMed |
description | Secretin (SCT) is a classical peptide hormone that is synthesized and released from the gastrointestinal tract after a meal. We have previously shown that it acts both as a central and peripheral anorectic peptide, and that its central effect is mediated via melanocortin system. As peripheral satiety signals from the gastrointestinal tract can be sent to the brain via the vagal afferent or by crossing the blood-brain barrier (BBB), we therefore sought to investigate the pathway by which peripheral SCT reduces appetite in this study. It is found that bilateral subdiaphragmatic vagotomy and treatment of capsaicin, an excitotoxin for primary afferent neurons, could both block the anorectic effect of peripherally injected SCT. These treatments are found to be capable of blunting i.p. SCT-induced Fos activation in pro-opiomelanocortin (POMC) neurons within the hypothalamic Arcuate Nucleus (Arc). Moreover, we have also found that bilateral midbrain transaction could block feeding reduction by peripheral SCT. Taken together, we conclude that the satiety signals of peripheral SCT released from the gastrointestinal tract are sent via the vagus nerves to the brainstem and subsequently Arc, where it controls central expression of other regulatory peptides to regulate food intake. |
format | Online Article Text |
id | pubmed-3667839 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-36678392013-06-04 Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin Chu, Jessica Y. S. Cheng, Carrie Y. Y. Sekar, Revathi Chow, Billy K. C. PLoS One Research Article Secretin (SCT) is a classical peptide hormone that is synthesized and released from the gastrointestinal tract after a meal. We have previously shown that it acts both as a central and peripheral anorectic peptide, and that its central effect is mediated via melanocortin system. As peripheral satiety signals from the gastrointestinal tract can be sent to the brain via the vagal afferent or by crossing the blood-brain barrier (BBB), we therefore sought to investigate the pathway by which peripheral SCT reduces appetite in this study. It is found that bilateral subdiaphragmatic vagotomy and treatment of capsaicin, an excitotoxin for primary afferent neurons, could both block the anorectic effect of peripherally injected SCT. These treatments are found to be capable of blunting i.p. SCT-induced Fos activation in pro-opiomelanocortin (POMC) neurons within the hypothalamic Arcuate Nucleus (Arc). Moreover, we have also found that bilateral midbrain transaction could block feeding reduction by peripheral SCT. Taken together, we conclude that the satiety signals of peripheral SCT released from the gastrointestinal tract are sent via the vagus nerves to the brainstem and subsequently Arc, where it controls central expression of other regulatory peptides to regulate food intake. Public Library of Science 2013-05-30 /pmc/articles/PMC3667839/ /pubmed/23738005 http://dx.doi.org/10.1371/journal.pone.0064859 Text en © 2013 Chu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Chu, Jessica Y. S. Cheng, Carrie Y. Y. Sekar, Revathi Chow, Billy K. C. Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin |
title | Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin |
title_full | Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin |
title_fullStr | Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin |
title_full_unstemmed | Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin |
title_short | Vagal Afferent Mediates the Anorectic Effect of Peripheral Secretin |
title_sort | vagal afferent mediates the anorectic effect of peripheral secretin |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667839/ https://www.ncbi.nlm.nih.gov/pubmed/23738005 http://dx.doi.org/10.1371/journal.pone.0064859 |
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