Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans

Candida albicans is the most common human fungal pathogen. Many organisms, including C. albicans, secrete glucanases under different environmental conditions. Here, we report a novel role for beta-1, 3- glucanase in inducing Candida albicans to form filaments at 22°C and enhancing filamentation at 3...

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Detalles Bibliográficos
Autores principales: Xu, Hongbin, Nobile, Clarissa J., Dongari-Bagtzoglou, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667860/
https://www.ncbi.nlm.nih.gov/pubmed/23737947
http://dx.doi.org/10.1371/journal.pone.0063736
Descripción
Sumario:Candida albicans is the most common human fungal pathogen. Many organisms, including C. albicans, secrete glucanases under different environmental conditions. Here, we report a novel role for beta-1, 3- glucanase in inducing Candida albicans to form filaments at 22°C and enhancing filamentation at 37°C in nutrient-rich medium. Quorum sensing, the efg1-signaling and cek1 MAP kinase pathways are involved in this process. Our data suggest that the natural antifungal agent beta–glucanase may support morphologic transformation of Candida albicans at a wide range of ambient temperatures.

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