Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans

Candida albicans is the most common human fungal pathogen. Many organisms, including C. albicans, secrete glucanases under different environmental conditions. Here, we report a novel role for beta-1, 3- glucanase in inducing Candida albicans to form filaments at 22°C and enhancing filamentation at 3...

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Detalles Bibliográficos
Autores principales: Xu, Hongbin, Nobile, Clarissa J., Dongari-Bagtzoglou, Anna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667860/
https://www.ncbi.nlm.nih.gov/pubmed/23737947
http://dx.doi.org/10.1371/journal.pone.0063736
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author Xu, Hongbin
Nobile, Clarissa J.
Dongari-Bagtzoglou, Anna
author_facet Xu, Hongbin
Nobile, Clarissa J.
Dongari-Bagtzoglou, Anna
author_sort Xu, Hongbin
collection PubMed
description Candida albicans is the most common human fungal pathogen. Many organisms, including C. albicans, secrete glucanases under different environmental conditions. Here, we report a novel role for beta-1, 3- glucanase in inducing Candida albicans to form filaments at 22°C and enhancing filamentation at 37°C in nutrient-rich medium. Quorum sensing, the efg1-signaling and cek1 MAP kinase pathways are involved in this process. Our data suggest that the natural antifungal agent beta–glucanase may support morphologic transformation of Candida albicans at a wide range of ambient temperatures.
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spelling pubmed-36678602013-06-04 Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans Xu, Hongbin Nobile, Clarissa J. Dongari-Bagtzoglou, Anna PLoS One Research Article Candida albicans is the most common human fungal pathogen. Many organisms, including C. albicans, secrete glucanases under different environmental conditions. Here, we report a novel role for beta-1, 3- glucanase in inducing Candida albicans to form filaments at 22°C and enhancing filamentation at 37°C in nutrient-rich medium. Quorum sensing, the efg1-signaling and cek1 MAP kinase pathways are involved in this process. Our data suggest that the natural antifungal agent beta–glucanase may support morphologic transformation of Candida albicans at a wide range of ambient temperatures. Public Library of Science 2013-05-30 /pmc/articles/PMC3667860/ /pubmed/23737947 http://dx.doi.org/10.1371/journal.pone.0063736 Text en © 2013 Xu et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Xu, Hongbin
Nobile, Clarissa J.
Dongari-Bagtzoglou, Anna
Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans
title Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans
title_full Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans
title_fullStr Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans
title_full_unstemmed Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans
title_short Glucanase Induces Filamentation of the Fungal Pathogen Candida albicans
title_sort glucanase induces filamentation of the fungal pathogen candida albicans
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667860/
https://www.ncbi.nlm.nih.gov/pubmed/23737947
http://dx.doi.org/10.1371/journal.pone.0063736
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