Inhibition of TDP-43 Aggregation by Nucleic Acid Binding

The aggregation of TAR DNA-binding protein (TDP-43) has been shown as a hallmark of amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) since 2006. While evidence has suggested that mutation or truncation in TDP-43 influences its aggregation process, nevertheless, the co...

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Detalles Bibliográficos
Autores principales: Huang, Yi-Chen, Lin, Ku-Feng, He, Ruei-Yu, Tu, Pang-Hsien, Koubek, Jiri, Hsu, Yin-Chih, Huang, Joseph Jen-Tse
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667863/
https://www.ncbi.nlm.nih.gov/pubmed/23737961
http://dx.doi.org/10.1371/journal.pone.0064002

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