Homology model and targeted mutagenesis identify critical residues for arachidonic acid inhibition of Kv4 channels

Polyunsaturated fatty acids such as arachidonic acid (AA) exhibit inhibitory modulation of Kv4 potassium channels. Molecular docking approaches using a Kv4.2 homology model predicted a membrane-embedded binding pocket for AA comprised of the S4-S5 linker on one subunit and several hydrophobic residu...

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Detalles Bibliográficos
Autores principales: Heler, Robert, Bell, Jessica K., Boland, Linda M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667888/
https://www.ncbi.nlm.nih.gov/pubmed/23334377
http://dx.doi.org/10.4161/chan.23453

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667888/
https://www.ncbi.nlm.nih.gov/pubmed/23334377
http://dx.doi.org/10.4161/chan.23453

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