The two faces of regulatory T cells in cancer

Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt...

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Detalles Bibliográficos
Autores principales: Blatner, Nichole R, Gounari, Fotini, Khazaie, Khashayarsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667893/
https://www.ncbi.nlm.nih.gov/pubmed/23762787
http://dx.doi.org/10.4161/onci.23852
Descripción
Sumario:Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients.

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