The two faces of regulatory T cells in cancer

Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt...

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Detalles Bibliográficos
Autores principales: Blatner, Nichole R, Gounari, Fotini, Khazaie, Khashayarsha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667893/
https://www.ncbi.nlm.nih.gov/pubmed/23762787
http://dx.doi.org/10.4161/onci.23852
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author Blatner, Nichole R
Gounari, Fotini
Khazaie, Khashayarsha
author_facet Blatner, Nichole R
Gounari, Fotini
Khazaie, Khashayarsha
author_sort Blatner, Nichole R
collection PubMed
description Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients.
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spelling pubmed-36678932013-06-12 The two faces of regulatory T cells in cancer Blatner, Nichole R Gounari, Fotini Khazaie, Khashayarsha Oncoimmunology Author's View Regulatory T cells (Tregs) that expand in human colon cancer express retinoid-related orphan receptor γt (RORγt) and exert potent T-cell suppressive functions while mediating pro-inflammatory effects. Similar Tregs expand and drive a vicious cycle of inflammation in murine polyposis. Targeting RORγt in Tregs interrupts such a cycle and protects mice against polyposis, suggesting that a similar intervention may provide therapeutic benefits to colon cancer patients. Landes Bioscience 2013-05-01 2013-04-15 /pmc/articles/PMC3667893/ /pubmed/23762787 http://dx.doi.org/10.4161/onci.23852 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Blatner, Nichole R
Gounari, Fotini
Khazaie, Khashayarsha
The two faces of regulatory T cells in cancer
title The two faces of regulatory T cells in cancer
title_full The two faces of regulatory T cells in cancer
title_fullStr The two faces of regulatory T cells in cancer
title_full_unstemmed The two faces of regulatory T cells in cancer
title_short The two faces of regulatory T cells in cancer
title_sort two faces of regulatory t cells in cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667893/
https://www.ncbi.nlm.nih.gov/pubmed/23762787
http://dx.doi.org/10.4161/onci.23852
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