Prognostic value of the immune microenvironment in lung adenocarcinoma

We analyzed the immune microenvironment in the neoplastic and stromal components of Stage I lung adenocarcinoma lesions, finding that a high ratio of tumor-infiltrating FOXP3(+) regulatory T cells to CD3(+) lymphocytes, an elevated expression of the interleukin-7 receptor, as well as a reduced expre...

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Autores principales: Kadota, Kyuichi, Nitadori, Jun-ichi, Adusumilli, Prasad S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667898/
https://www.ncbi.nlm.nih.gov/pubmed/23762792
http://dx.doi.org/10.4161/onci.24036
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author Kadota, Kyuichi
Nitadori, Jun-ichi
Adusumilli, Prasad S.
author_facet Kadota, Kyuichi
Nitadori, Jun-ichi
Adusumilli, Prasad S.
author_sort Kadota, Kyuichi
collection PubMed
description We analyzed the immune microenvironment in the neoplastic and stromal components of Stage I lung adenocarcinoma lesions, finding that a high ratio of tumor-infiltrating FOXP3(+) regulatory T cells to CD3(+) lymphocytes, an elevated expression of the interleukin-7 receptor, as well as a reduced expression of the interleukin-12 receptor β2 all constitute independent factors of poor prognosis.
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spelling pubmed-36678982013-06-12 Prognostic value of the immune microenvironment in lung adenocarcinoma Kadota, Kyuichi Nitadori, Jun-ichi Adusumilli, Prasad S. Oncoimmunology Author's View We analyzed the immune microenvironment in the neoplastic and stromal components of Stage I lung adenocarcinoma lesions, finding that a high ratio of tumor-infiltrating FOXP3(+) regulatory T cells to CD3(+) lymphocytes, an elevated expression of the interleukin-7 receptor, as well as a reduced expression of the interleukin-12 receptor β2 all constitute independent factors of poor prognosis. Landes Bioscience 2013-05-01 2013-05-01 /pmc/articles/PMC3667898/ /pubmed/23762792 http://dx.doi.org/10.4161/onci.24036 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Kadota, Kyuichi
Nitadori, Jun-ichi
Adusumilli, Prasad S.
Prognostic value of the immune microenvironment in lung adenocarcinoma
title Prognostic value of the immune microenvironment in lung adenocarcinoma
title_full Prognostic value of the immune microenvironment in lung adenocarcinoma
title_fullStr Prognostic value of the immune microenvironment in lung adenocarcinoma
title_full_unstemmed Prognostic value of the immune microenvironment in lung adenocarcinoma
title_short Prognostic value of the immune microenvironment in lung adenocarcinoma
title_sort prognostic value of the immune microenvironment in lung adenocarcinoma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667898/
https://www.ncbi.nlm.nih.gov/pubmed/23762792
http://dx.doi.org/10.4161/onci.24036
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AT nitadorijunichi prognosticvalueoftheimmunemicroenvironmentinlungadenocarcinoma
AT adusumilliprasads prognosticvalueoftheimmunemicroenvironmentinlungadenocarcinoma

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