EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies

Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumo...

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Detalles Bibliográficos
Autores principales: Derer, Stefanie, Lohse, Stefan, Valerius, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667899/
https://www.ncbi.nlm.nih.gov/pubmed/23762793
http://dx.doi.org/10.4161/onci.24052
Descripción
Sumario:Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting antibodies depend on EGFR expression levels.

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