EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies

Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumo...

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Detalles Bibliográficos
Autores principales: Derer, Stefanie, Lohse, Stefan, Valerius, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667899/
https://www.ncbi.nlm.nih.gov/pubmed/23762793
http://dx.doi.org/10.4161/onci.24052
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author Derer, Stefanie
Lohse, Stefan
Valerius, Thomas
author_facet Derer, Stefanie
Lohse, Stefan
Valerius, Thomas
author_sort Derer, Stefanie
collection PubMed
description Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting antibodies depend on EGFR expression levels.
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spelling pubmed-36678992013-06-12 EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies Derer, Stefanie Lohse, Stefan Valerius, Thomas Oncoimmunology Author's View Epidermal growth factor receptor (EGFR) expression levels appear to modulate the efficacy of EGFR-targeting monoclonal antibodies. More specifically, we observed that high EGFR densities negatively affect the effects of EGFR-specific antibodies on EGFR phosphorylation yet exacerbate Fc-mediated tumor-cell killing. These results suggest that the predominant mode of action of EGFR-targeting antibodies depend on EGFR expression levels. Landes Bioscience 2013-05-01 2013-05-01 /pmc/articles/PMC3667899/ /pubmed/23762793 http://dx.doi.org/10.4161/onci.24052 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Derer, Stefanie
Lohse, Stefan
Valerius, Thomas
EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies
title EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies
title_full EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies
title_fullStr EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies
title_full_unstemmed EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies
title_short EGFR expression levels affect the mode of action of EGFR-targeting monoclonal antibodies
title_sort egfr expression levels affect the mode of action of egfr-targeting monoclonal antibodies
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667899/
https://www.ncbi.nlm.nih.gov/pubmed/23762793
http://dx.doi.org/10.4161/onci.24052
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AT valeriusthomas egfrexpressionlevelsaffectthemodeofactionofegfrtargetingmonoclonalantibodies

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