Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma

Human papillomavirus (HPV) types associated with head and neck cancer generally induce a robust immune response. Despite the establishment of such an inflammatory microenvironment, HPV is able to persist and promote malignant transformation. The PD-1:PD-L1 immune checkpoint may play a critical role...

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Detalles Bibliográficos
Autor principal: Pai, Sara I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667901/
https://www.ncbi.nlm.nih.gov/pubmed/23762795
http://dx.doi.org/10.4161/onci.24065
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author Pai, Sara I.
author_facet Pai, Sara I.
author_sort Pai, Sara I.
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description Human papillomavirus (HPV) types associated with head and neck cancer generally induce a robust immune response. Despite the establishment of such an inflammatory microenvironment, HPV is able to persist and promote malignant transformation. The PD-1:PD-L1 immune checkpoint may play a critical role in the creation of an immunoprivileged site for viral persistence and the subsequent development of cancer.
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spelling pubmed-36679012013-06-12 Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma Pai, Sara I. Oncoimmunology Author's View Human papillomavirus (HPV) types associated with head and neck cancer generally induce a robust immune response. Despite the establishment of such an inflammatory microenvironment, HPV is able to persist and promote malignant transformation. The PD-1:PD-L1 immune checkpoint may play a critical role in the creation of an immunoprivileged site for viral persistence and the subsequent development of cancer. Landes Bioscience 2013-05-01 2013-05-01 /pmc/articles/PMC3667901/ /pubmed/23762795 http://dx.doi.org/10.4161/onci.24065 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Pai, Sara I.
Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma
title Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma
title_full Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma
title_fullStr Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma
title_full_unstemmed Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma
title_short Adaptive immune resistance in HPV-associated head and neck squamous cell carcinoma
title_sort adaptive immune resistance in hpv-associated head and neck squamous cell carcinoma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667901/
https://www.ncbi.nlm.nih.gov/pubmed/23762795
http://dx.doi.org/10.4161/onci.24065
work_keys_str_mv AT paisarai adaptiveimmuneresistanceinhpvassociatedheadandnecksquamouscellcarcinoma

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