Thwarting galectin-induced immunosuppression in breast cancer

Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4(+)CD25(+) FOXP3(+)...

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Detalles Bibliográficos
Autores principales: Salatino, Mariana, Dalotto-Moreno, Tomas, Rabinovich, Gabriel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667902/
https://www.ncbi.nlm.nih.gov/pubmed/23762796
http://dx.doi.org/10.4161/onci.24077
Descripción
Sumario:Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4(+)CD25(+) FOXP3(+) regulatory T cells.

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