Thwarting galectin-induced immunosuppression in breast cancer

Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4(+)CD25(+) FOXP3(+)...

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Detalles Bibliográficos
Autores principales: Salatino, Mariana, Dalotto-Moreno, Tomas, Rabinovich, Gabriel A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667902/
https://www.ncbi.nlm.nih.gov/pubmed/23762796
http://dx.doi.org/10.4161/onci.24077
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author Salatino, Mariana
Dalotto-Moreno, Tomas
Rabinovich, Gabriel A.
author_facet Salatino, Mariana
Dalotto-Moreno, Tomas
Rabinovich, Gabriel A.
author_sort Salatino, Mariana
collection PubMed
description Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4(+)CD25(+) FOXP3(+) regulatory T cells.
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spelling pubmed-36679022013-06-12 Thwarting galectin-induced immunosuppression in breast cancer Salatino, Mariana Dalotto-Moreno, Tomas Rabinovich, Gabriel A. Oncoimmunology Author's View Novel therapeutic strategies are needed to counteract breast cancer-associated immunosuppression. Silencing the expression of galectin-1 in a breast carcinoma model inhibited tumor growth and prevented lung metastasis by reducing the frequency and immunosuppressive activity of CD4(+)CD25(+) FOXP3(+) regulatory T cells. Landes Bioscience 2013-05-01 2013-05-01 /pmc/articles/PMC3667902/ /pubmed/23762796 http://dx.doi.org/10.4161/onci.24077 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Salatino, Mariana
Dalotto-Moreno, Tomas
Rabinovich, Gabriel A.
Thwarting galectin-induced immunosuppression in breast cancer
title Thwarting galectin-induced immunosuppression in breast cancer
title_full Thwarting galectin-induced immunosuppression in breast cancer
title_fullStr Thwarting galectin-induced immunosuppression in breast cancer
title_full_unstemmed Thwarting galectin-induced immunosuppression in breast cancer
title_short Thwarting galectin-induced immunosuppression in breast cancer
title_sort thwarting galectin-induced immunosuppression in breast cancer
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667902/
https://www.ncbi.nlm.nih.gov/pubmed/23762796
http://dx.doi.org/10.4161/onci.24077
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