Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review

Trichosanthin (TCS) as a midterm abortifacient medicine has been used clinically in traditional Chinese medicine for centuries. Additionally, TCS manifests a host of pharmacological properties, for instance, anti-HIV and anti-tumor activities. TCS has been reported to inhibit cell growth of a divers...

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Detalles Bibliográficos
Autores principales: Sha, Ou, Niu, Junfei, Ng, Tzi-Bun, Cho, Eric Yu-Pang, Fu, Xiaoyuan, Jiang, Wenqi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2013
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668121/
https://www.ncbi.nlm.nih.gov/pubmed/23377374
http://dx.doi.org/10.1007/s00280-013-2096-y
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author Sha, Ou
Niu, Junfei
Ng, Tzi-Bun
Cho, Eric Yu-Pang
Fu, Xiaoyuan
Jiang, Wenqi
author_facet Sha, Ou
Niu, Junfei
Ng, Tzi-Bun
Cho, Eric Yu-Pang
Fu, Xiaoyuan
Jiang, Wenqi
author_sort Sha, Ou
collection PubMed
description Trichosanthin (TCS) as a midterm abortifacient medicine has been used clinically in traditional Chinese medicine for centuries. Additionally, TCS manifests a host of pharmacological properties, for instance, anti-HIV and anti-tumor activities. TCS has been reported to inhibit cell growth of a diversity of cancers, including cervical cancer, choriocarcinoma, and leukemia/lymphoma, etc. This article purported to review the various anti-tumor activities of TCS and the mechanism of apoptosis it induced in these tumor cells. These research progresses provide an insight into cancer research and treatment as well as disclose new pharmacological properties of the ancient but popular Chinese medicine.
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spelling pubmed-36681212013-06-03 Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review Sha, Ou Niu, Junfei Ng, Tzi-Bun Cho, Eric Yu-Pang Fu, Xiaoyuan Jiang, Wenqi Cancer Chemother Pharmacol Review Article Trichosanthin (TCS) as a midterm abortifacient medicine has been used clinically in traditional Chinese medicine for centuries. Additionally, TCS manifests a host of pharmacological properties, for instance, anti-HIV and anti-tumor activities. TCS has been reported to inhibit cell growth of a diversity of cancers, including cervical cancer, choriocarcinoma, and leukemia/lymphoma, etc. This article purported to review the various anti-tumor activities of TCS and the mechanism of apoptosis it induced in these tumor cells. These research progresses provide an insight into cancer research and treatment as well as disclose new pharmacological properties of the ancient but popular Chinese medicine. Springer-Verlag 2013-02-03 2013 /pmc/articles/PMC3668121/ /pubmed/23377374 http://dx.doi.org/10.1007/s00280-013-2096-y Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Review Article
Sha, Ou
Niu, Junfei
Ng, Tzi-Bun
Cho, Eric Yu-Pang
Fu, Xiaoyuan
Jiang, Wenqi
Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review
title Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review
title_full Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review
title_fullStr Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review
title_full_unstemmed Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review
title_short Anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional Chinese medicine: a mini review
title_sort anti-tumor action of trichosanthin, a type 1 ribosome-inactivating protein, employed in traditional chinese medicine: a mini review
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668121/
https://www.ncbi.nlm.nih.gov/pubmed/23377374
http://dx.doi.org/10.1007/s00280-013-2096-y
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