Cargando…

Systematic antibody generation and validation via tissue microarray technology leading to identification of a novel protein prognostic panel in breast cancer

BACKGROUND: Although omic-based discovery approaches can provide powerful tools for biomarker identification, several reservations have been raised regarding the clinical applicability of gene expression studies, such as their prohibitive cost. However, the limited availability of antibodies is a ke...

Descripción completa

Detalles Bibliográficos
Autores principales:	O´Leary, Patrick C, Penny, Sarah A, Dolan, Roisin T, Kelly, Catherine M, Madden, Stephen F, Rexhepaj, Elton, Brennan, Donal J, McCann, Amanda H, Pontén, Fredrik, Uhlén, Mathias, Zagozdzon, Radoslaw, Duffy, Michael J, Kell, Malcolm R, Jirström, Karin, Gallagher, William M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668187/ https://www.ncbi.nlm.nih.gov/pubmed/23547718 http://dx.doi.org/10.1186/1471-2407-13-175

Ejemplares similares

Tumour-specific HMG-CoAR is an independent predictor of recurrence free survival in epithelial ovarian cancer
por: Brennan, Donal J, et al.
Publicado: (2010)

A Texture Based Pattern Recognition Approach to Distinguish Melanoma from Non-Melanoma Cells in Histopathological Tissue Microarray Sections
por: Rexhepaj, Elton, et al.
Publicado: (2013)

Novel image analysis approach for quantifying expression of nuclear proteins assessed by immunohistochemistry: application to measurement of oestrogen and progesterone receptor levels in breast cancer
por: Rexhepaj, Elton, et al.
Publicado: (2008)

Validation of cytoplasmic-to-nuclear ratio of survivin as an indicator of improved prognosis in breast cancer
por: Rexhepaj, Elton, et al.
Publicado: (2010)

The tumour suppressor SOX11 is associated with improved survival among high grade epithelial ovarian cancers and is regulated by reversible promoter methylation
por: Sernbo, Sandra, et al.
Publicado: (2011)

Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer
por: O’Leary, Patrick C, et al.
Publicado: (2014)

Tumor-specific HMG-CoA reductase expression in primary premenopausal breast cancer predicts response to tamoxifen
por: Brennan, Donal J, et al.
Publicado: (2011)

Prognostic impact of tumour-specific HMG-CoA reductase expression in primary breast cancer
por: Borgquist, Signe, et al.
Publicado: (2008)

ANLN is a prognostic biomarker independent of Ki-67 and essential for cell cycle progression in primary breast cancer
por: Magnusson, Kristina, et al.
Publicado: (2016)

Low RBM3 protein expression correlates with tumour progression and poor prognosis in malignant melanoma: An analysis of 215 cases from the Malmö Diet and Cancer Study
por: Jonsson, Liv, et al.
Publicado: (2011)

Expression of the RNA-binding protein RBM3 is associated with a favourable prognosis and cisplatin sensitivity in epithelial ovarian cancer
por: Ehlén, Åsa, et al.
Publicado: (2010)

Prognostic ability of a panel of immunohistochemistry markers – retailoring of an 'old solution'
por: Brennan, Donal J, et al.
Publicado: (2008)

Generation of a new bioluminescent model for visualisation of mammary tumour development in transgenic mice
por: Zagozdzon, Agnieszka M, et al.
Publicado: (2012)

Identification of a myometrial molecular profile for dystocic labor
por: Brennan, Donal J, et al.
Publicado: (2011)

The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients
por: Medrek, Catharina, et al.
Publicado: (2012)

Analysis of the Human Prostate-Specific Proteome Defined by Transcriptomics and Antibody-Based Profiling Identifies TMEM79 and ACOXL as Two Putative, Diagnostic Markers in Prostate Cancer
por: O'Hurley, Gillian, et al.
Publicado: (2015)

Production of Tissue Microarrays, Immunohistochemistry Staining and Digitalization Within the Human Protein Atlas
por: Kampf, Caroline, et al.
Publicado: (2012)

Homeobox transcription factor muscle segment homeobox 2 (Msx2) correlates with good prognosis in breast cancer patients and induces apoptosis in vitro
por: Lanigan, Fiona, et al.
Publicado: (2010)

Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray
por: Möllerström, Elin, et al.
Publicado: (2010)

The Urinary Bladder Transcriptome and Proteome Defined by Transcriptomics and Antibody-Based Profiling
por: Habuka, Masato, et al.
Publicado: (2015)

Transcriptomics resources of human tissues and organs
por: Uhlén, Mathias, et al.
Publicado: (2016)

Gene‐specific correlation of RNA and protein levels in human cells and tissues
por: Edfors, Fredrik, et al.
Publicado: (2016)

Correlations between RNA and protein expression profiles in 23 human cell lines
por: Gry, Marcus, et al.
Publicado: (2009)

In silico analysis of microRNA-510 as a potential oncomir in human breast cancer
por: Gaj, Pawel, et al.
Publicado: (2014)

Cancer stem cells in haematological malignancies
por: Zagozdzon, Radoslaw, et al.
Publicado: (2015)

Predicted long-term mortality reduction associated with the second round of breast screening in East Anglia
por: McCann, J, et al.
Publicado: (2001)

Discovery of dachshund 2 protein as a novel biomarker of poor prognosis in epithelial ovarian cancer
por: Nodin, Björn, et al.
Publicado: (2012)

Expression of the global regulator SATB1 is an independent factor of poor prognosis in high grade epithelial ovarian cancer
por: Nodin, Björn, et al.
Publicado: (2012)

High RBM3 expression is associated with an improved survival and oxaliplatin response in patients with metastatic colorectal cancer
por: Siesing, Christina, et al.
Publicado: (2017)

Absolute Quantification of Pan-Cancer Plasma Proteomes Reveals Unique Signature in Multiple Myeloma
por: Kotol, David, et al.
Publicado: (2023)

Interleukin 12: still a promising candidate for tumor immunotherapy?
por: Lasek, Witold, et al.
Publicado: (2014)

Modulation of the Immune System in Chronic Hepatitis C and During Antiviral Interferon-Free Therapy
por: Urbanowicz, Arkadiusz, et al.
Publicado: (2018)

Immune Evasion as the Main Challenge for Immunotherapy of Cancer
por: Zagozdzon, Radoslaw, et al.
Publicado: (2022)

A tool to facilitate clinical biomarker studies - a tissue dictionary based on the Human Protein Atlas
por: Kampf, Caroline, et al.
Publicado: (2012)

The Human Pancreas Proteome Defined by Transcriptomics and Antibody-Based Profiling
por: Danielsson, Angelika, et al.
Publicado: (2014)

Application of Genome Editing Techniques in Immunology
por: Zych, Agata O., et al.
Publicado: (2018)

Increased androgen receptor expression in serous carcinoma of the ovary is associated with an improved survival
por: Nodin, Björn, et al.
Publicado: (2010)

Oxidative Stress in Kidney Diseases: The Cause or the Consequence?
por: Krata, Natalia, et al.
Publicado: (2017)

Osteopontin Gene Polymorphism and Urinary OPN Excretion in Patients with Immunoglobulin A Nephropathy
por: Kaleta, Beata, et al.
Publicado: (2019)

Immunomodulatory Properties of Polysaccharides from Lentinula edodes
por: Roszczyk, Aleksander, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_aut2fmqiutki5p211fhtc0f9fv