Treatment with CNX-011-67, a novel GPR40 agonist, delays onset and progression of diabetes and improves beta cell preservation and function in male ZDF rats

BACKGROUND: The role of G protein-coupled receptor (GPR40), which is highly expressed in pancreatic beta cells, has been studied extensively in the amelioration of beta cell dysfunction in T2D using rat and mouse islets, beta cell lines and in animal models of diabetes. But its potential as a therap...

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Detalles Bibliográficos
Autores principales: Gowda, Nagesh, Dandu, Anilkumar, Singh, Jaideep, Biswas, Sanghamitra, Raghav, Vijaya, Lakshmi, Mudigere N, Shilpa, Pavagada C, Sunil, Venkategowda, Reddy, Ashokkumar, Sadasivuni, Manojkumar, Aparna, Kumaraswamy, Verma, Mahesh Kumar, Moolemath, Yoganand, Anup, Mammen O, Venkataranganna, Marikunte V, Somesh, Baggavalli P, Jagannath, Madanahalli R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668190/
https://www.ncbi.nlm.nih.gov/pubmed/23692921
http://dx.doi.org/10.1186/2050-6511-14-28

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