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A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China

BACKGROUND: Insecticide resistance in malaria vectors is a growing concern in many countries and requires immediate attention because of the limited chemical arsenal available for vector control. There is lack of systematic and standard monitoring data of malaria vector resistance in the endemic are...

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Autores principales: Wang, Duo-quan, Xia, Zhi-gui, Zhou, Shui-sen, Zhou, Xiao-nong, Wang, Ru-bo, Zhang, Qing-feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668211/
https://www.ncbi.nlm.nih.gov/pubmed/23683359
http://dx.doi.org/10.1186/1475-2875-12-164
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author Wang, Duo-quan
Xia, Zhi-gui
Zhou, Shui-sen
Zhou, Xiao-nong
Wang, Ru-bo
Zhang, Qing-feng
author_facet Wang, Duo-quan
Xia, Zhi-gui
Zhou, Shui-sen
Zhou, Xiao-nong
Wang, Ru-bo
Zhang, Qing-feng
author_sort Wang, Duo-quan
collection PubMed
description BACKGROUND: Insecticide resistance in malaria vectors is a growing concern in many countries and requires immediate attention because of the limited chemical arsenal available for vector control. There is lack of systematic and standard monitoring data of malaria vector resistance in the endemic areas, which is essential for the ambitious goal of malaria elimination programme of China. METHODS: In 2010, eight provinces from different malaria endemic region were selected for study areas. Bioassays were performed on F1 progeny of Anopheles sinensis reared from wild-caught females using the standard WHO susceptibility test with diagnostic concentrations of 0.25% deltamethrin and 4% DDT. RESULTS: For An. sinensis, the results indicated that exposure to 0.25% deltamethrin of F1 families with mortalities ranging from 5.96% to 64.54% and less than 80% mortality to DDT at the diagnostic concentration of 4% across the study areas. CONCLUSIONS: Anopheles sinensis was completely resistant to both deltamethrin and DDT, and resistance to pyrethroid has risen strikingly compared to that recorded during 1990s. The results highlight the importance of longitudinal insecticide resistance monitoring and the urgent need for a better understanding of the status of insecticide resistance in this region.
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spelling pubmed-36682112013-06-01 A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China Wang, Duo-quan Xia, Zhi-gui Zhou, Shui-sen Zhou, Xiao-nong Wang, Ru-bo Zhang, Qing-feng Malar J Research BACKGROUND: Insecticide resistance in malaria vectors is a growing concern in many countries and requires immediate attention because of the limited chemical arsenal available for vector control. There is lack of systematic and standard monitoring data of malaria vector resistance in the endemic areas, which is essential for the ambitious goal of malaria elimination programme of China. METHODS: In 2010, eight provinces from different malaria endemic region were selected for study areas. Bioassays were performed on F1 progeny of Anopheles sinensis reared from wild-caught females using the standard WHO susceptibility test with diagnostic concentrations of 0.25% deltamethrin and 4% DDT. RESULTS: For An. sinensis, the results indicated that exposure to 0.25% deltamethrin of F1 families with mortalities ranging from 5.96% to 64.54% and less than 80% mortality to DDT at the diagnostic concentration of 4% across the study areas. CONCLUSIONS: Anopheles sinensis was completely resistant to both deltamethrin and DDT, and resistance to pyrethroid has risen strikingly compared to that recorded during 1990s. The results highlight the importance of longitudinal insecticide resistance monitoring and the urgent need for a better understanding of the status of insecticide resistance in this region. BioMed Central 2013-05-17 /pmc/articles/PMC3668211/ /pubmed/23683359 http://dx.doi.org/10.1186/1475-2875-12-164 Text en Copyright © 2013 Wang et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Wang, Duo-quan
Xia, Zhi-gui
Zhou, Shui-sen
Zhou, Xiao-nong
Wang, Ru-bo
Zhang, Qing-feng
A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China
title A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China
title_full A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China
title_fullStr A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China
title_full_unstemmed A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China
title_short A potential threat to malaria elimination: extensive deltamethrin and DDT resistance to Anopheles sinensis from the malaria-endemic areas in China
title_sort potential threat to malaria elimination: extensive deltamethrin and ddt resistance to anopheles sinensis from the malaria-endemic areas in china
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668211/
https://www.ncbi.nlm.nih.gov/pubmed/23683359
http://dx.doi.org/10.1186/1475-2875-12-164
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