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Van-Gogh-like 2 antagonises the canonical WNT pathway and is methylated in colorectal cancers
BACKGROUND: Aberrant activation of the canonical WNT signaling is a feature of colorectal cancer (CRC). Van-Gogh-like 2 (VANGL2) belongs to the non-canonical WNT pathway whose activation inhibits canonical WNT signaling. In this study, we investigated the role of VANGL2 and its epigenetic regulation...
Autores principales: | Piazzi, G, Selgrad, M, Garcia, M, Ceccarelli, C, Fini, L, Bianchi, P, Laghi, L, D'Angelo, L, Paterini, P, Malfertheiner, P, Chieco, P, Boland, C R, Bazzoli, F, Ricciardiello, L |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668461/ https://www.ncbi.nlm.nih.gov/pubmed/23579212 http://dx.doi.org/10.1038/bjc.2013.142 |
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