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Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib

BACKGROUND: Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the ‘Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it...

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Detalles Bibliográficos
Autores principales:	Sanchez, W Y, McGee, S L, Connor, T, Mottram, B, Wilkinson, A, Whitehead, J P, Vuckovic, S, Catley, L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2013
Materias:	Translational Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668464/ https://www.ncbi.nlm.nih.gov/pubmed/23531700 http://dx.doi.org/10.1038/bjc.2013.120

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